Impact of Mono-therapy Antiepileptic Drugs on lipid profile of epileptic children | ||||
| Minia Journal of Medical Research | ||||
| Article 28, Volume 30, Issue 4, October 2019, Page 168-174 PDF (312.31 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221708 | ||||
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| Authors | ||||
| E. M. Soliman1; G. T. Solimanm2; L. M. Abo-Elfotoh2; Marwa Waly El-Din Ali1 | ||||
| 1Department of Neurology, El-Minia university Egypt | ||||
| 2Department of Pediatric, El-Minia university Egypt | ||||
| Abstract | ||||
| Background: Epilepsy is one of the most common neurological disorders, which required long term therapy or lifelong treatment in some cases. Chronic use of antiepileptic drugs (AEDs) therapy might modify some vascular risk factors, Since atherosclerotic vascular alterations may start early in life, this study focuses on dyslipidemia which is a major atherogenic risk factor among epileptic children. The aim of this study: to evaluate different effects of mono-therapy antiepileptic drugs (AEDs) on lipid profile of children with idiopathic epilepsy. Methods: this study was carried out on 80 children , their age rage (7- 16) divided into group I included 20 healthy children their age and sex matched served as a control ,group II included 20 newly diagnosed epileptic children ( according to ILAE2014 diagnostic criteria of epilepsy ) they didn't receive medication till the time of study and and lastly group III included epileptic children receiving monotherapy AEDs n=40 ,where the duration of treatment were not less than 2 months ; groupIII divided into four subgroup according to the type of AEDs . Measurement received for all participant include detailed history, clinical examination ,neurological examination and serum fasting lipid profile, while the analysis of seizure (onset ,type, frequency and classification of epilepsy according to (ILAE2017)) , inter-ictal EEG ,history of AEDs administration; daily dose and compliance to medication were for epileptic patient only. Result: serum TC, LDL were significantly higher in epileptic children receiving AEDs than control groups or group of newly diagnosed epileptic children , TG and VLDL were higher in epileptic children treated with old AEDs than other groups ,while newly diagnosed epileptic children have higher LDL than control group, on the other hand there is a significant higher HDL in epileptic children treated with new antiepileptic drugs than newly diagnosed epileptic children and epileptic children treated with old antiepileptic drugs. Conclusion: epilepsy and antiepileptic drugs especially old generation antiepileptic drugs are considered risk factors of dyslipidemias& atherosclerosis. We recommend routine monitoring of the serum lipid profile in epileptic children especially they treated with old generation AEDs (VAP and CBZ namely). | ||||
| Keywords | ||||
| epilepsy antiepileptic drugs AEDs serum lipid profile old AEDs new AEDs | ||||
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