The Effect of Phototherapy on Expression of Bax and Bcl2 Genes in Neonates with Jaundice | ||||
| Minia Journal of Medical Research | ||||
| Article 29, Volume 30, Issue 4, October 2019, Page 175-181 PDF (424.47 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221709 | ||||
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| Authors | ||||
| Mohamed F. Afifi1; Abdel Hakeem A. Abdel Hakeem2; Emad A. Abd El naeem3; Marwa I. Abd Elrazic2 | ||||
| 1Department of Pediatrics, El-Minia Faculty of Medicine, El Minia, Egypt | ||||
| 2Department of Pediatrics, El-Minia Faculty of Medicine, El Minia, Egypt. | ||||
| 3Department of Clinical pathology, El-Minia Faculty of Medicine, El Minia, Egypt. | ||||
| Abstract | ||||
| Objectives: to evaluate the effect of phototherapy on expression of BAX and Bcl2 genes in full term with hyperbilirubinemia. It comprised 18 full term and 18 preterm neonates with indirect hyperbilirubinemia who received phototherapy for 24 h, and 9 apparently healthy full term and 9 helthy preterm neonates with normal serum bilirubin level, as a control group. Determination: of the anti-apoptotic effect(s) of BCL2 gene and the pro-apoptotic effect(s) of (Bax) gene was achieved by quantitative assay of its product, (BCL2) protein, and BAX protein by ELISA. Results: there were significant decrease in the serum levels of bcl2 after phototherapy (P =0.001) and significant increase in serum levels of Bax protein after phototherapy (P <0.001) in hyperbilirubinemic full term neonates. Conclusion: Hyperbilirubinemia does not influence on apoptosis, whereas phototherapy does and induces apoptosis in peripheral blood of hyperbilirubinemic full-term infants. | ||||
| Keywords | ||||
| hyperbilirubinemic; phototherapy; apoptosis | ||||
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