Histological changes in the substantia nigra in Parkinsonism model in male albino rat | ||||
| Minia Journal of Medical Research | ||||
| Article 32, Volume 30, Issue 4, October 2019, Page 193-197 PDF (468.55 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221715 | ||||
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| Authors | ||||
| Soha A. Abdelwahab1; , Sara A. Elsebaay2; Manar F. Gaber Ibrahim1; Sara M. Naguib Abdel-Hafez3 | ||||
| 1Department of Histology and Cell Biology, Faculty of Medicine, Minia University. | ||||
| 2* Department Histology and Cell Biology, Faculty of Medicine, Ain Shams University | ||||
| 3Department of Histology and Cell Biology, Faculty of Medicine, Minia University | ||||
| Abstract | ||||
| The substantia nigra is a part of the basal ganglia that is present in the midbrain. It is characterized by the presence of dopaminergic neurons in the substantia nigra pars compacta. Parkinsonism disease is one of the most common neurodegenerative diseases affecting elderly patients. It occurs due to progressive degeneration of dopaminergic neurons in the substantia nigra. In this work, Parkinsonism was induced in rats by daily subcutaneous injection of 0.5mg/Kg of rotenone for 28 days. Twenty rats were divided randomly into 2 groups; control and Parkinsonism groups. Brain specimens were obtained for H&E stain. In Parkinsonism group, shrunken dopaminergic neurons with small dense nuclei and were surrounded with wide pericellular hallows were frequently observed in the substantia nigra. Acidophilic lewy bodies are a very characteristic finding in Parkonsonism group. There was also vacuolation in the neuropil. | ||||
| Keywords | ||||
| substantia nigra; ganglia; dopaminergic neurons; Parkinsonism disease | ||||
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