Comparison between oral pregabalin and intravenous fentanyl on attenuation of blood glucose level as one modality of stress response to tracheal intubation and decreasing early post-operative pain | ||||
| Minia Journal of Medical Research | ||||
| Article 44, Volume 30, Issue 4, October 2019, Page 283-291 PDF (273.1 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221738 | ||||
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| Authors | ||||
| Mohamed Sh. Mohamed Abdullaah; Mohamed A. Ahmed; Rehab M. Abd Elaal Sayed | ||||
| Department of Anesthesia, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Introduction: Endotracheal tube remains the gold standard airway device for securing the airway during general anesthesia. However, Laryngoscopy and tracheal intubation are associated with haemodynamic stress responses due to sympathetic stimulation, which results in marked increase in heart rate, blood pressure, circulating catecholamines. Aim of the work: To evaluate the effect of oral pregabalin and intravenous fentanyl on attenuation of blood glucose level as one modality of the stress response to tracheal intubation and decrease early postoperative pain in elective upper abdominal surgeries. Patients and Methods: The study included seventy five (75) patients, aged 18-40 years old of both sex, ASA I or II, undergoing elective upper abdominal surgeries open cholecystectomy, renal stone ,pyeloplasty and nephrectomy under general anaesthesia with endotracheal intubation. The patients were randomly divided into one of three groups, of 25 patients each (using computer generated randomization list): *Group (I): received 2µg/kg fentanyl iv route , 5 minutes before surgery.*Group (II): received 150 mg pregabalin oral route two hours before surgery.*Group (III): Received 150 mg pregabalin oral 2 hours before surgery and 2µg/kg fentanyl 5 minutes before surgery. Results: As regard MAP, HR, RR were significant lower in both groups [I] & [ Ш] when compared to group [II] and signifacntly lower in group [I] when compared to group [Ш]. Although there was Statistically significant reduction in values of MAP and HR in varying degrees when compared with their baseline values, there was no clinically symptomatic hypotension, bradycardia or respiratory depression required any treatment with naloxone or supplemental oxygen. Discussion: laryngoscopy alone or with tracheal intubation increases the arterial blood pressure and catecholamine levels, while intubation significantly increases heart rate This can also lead to increased risk of myocardial ischemia during tracheal intubation.We recommend: using fentanyl (2µg/kg) intravenous 5 minutes and oral pregabalin (150 mg) 2 hours before operation for controlling of hemodynamic stress response and post operative analgesia also on attenuation of blood glucose level as one modality of stress response in patients undergoing upper abdominal surgeries under general anaesethsia | ||||
| Keywords | ||||
| ASA: American society of anaethesiology; Hr: Hour; BP: blood pressue; ET: endotracheal. | ||||
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