Effect of treatment by atomoxetine on the serum level of brain-derived neurotrophic factor in children with Attention Deficit Hyperactivity Disorder | ||||
Minia Journal of Medical Research | ||||
Article 49, Volume 30, Issue 4, October 2019, Page 317-323 PDF (141.17 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.221746 | ||||
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Authors | ||||
Mariam R. Younan1; Samira Z. Said1; , Samir M. Abd Alkarim2; Waleed M. Abd Alwahab1 | ||||
1Department of Pediatric, El-Minia Faculty of Medicine | ||||
2Department of Clinical Pathology, El-Minia Faculty of Medicine | ||||
Abstract | ||||
Objective: To assess the effect of treatment by Atomoxetine (ATX) on the serum level of Brain derived neurotrophic factor (BDNF) in children suffering from Attention deficit hyperactivity (ADHD) treated by ATX in Obstetrics, Gynecology and Pediatric Minia University Hospital, Minia city, Minia Governorate. Method: we studied 60 children who were subjected to the following tool; laboratory workup for serum level of BDNF. Results: The study revealed that there was significant decrease in serum BDNF level in ADHD children treated by ATX than in ADHD without medications, no significant difference in serum BDNF level between both patients and control groups. There was no difference between serum BDNF level and duration of treatment by ATX in children treated by it. There was highly significant negative correlation between serum BDNF level and Body mass index (BMI) in both patient groups. There was a highly significant negative correlation between serum BDNF level and age in patients groups. Conclusion:A significant decrease in serum BDNF level in ADHD children treated by ATX than in ADHD without medications, no significant difference in serum BDNF level between both patients and control groups. There was no difference between serum BDNF level and duration of treatment in group I. The majority of our results are to some extent matched with the literature of ADHD while some results aren’t the same, which may be attributed to cultural characteristics and socio demographic issues. | ||||
Keywords | ||||
Adhd; Bdnf; Atx | ||||
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