Correlation between Serum Visfatin, Blood Glucose, Lipid Metabolism and Nonalcoholic Fatty liver Disease in Simple Obese Children. | ||||
Minia Journal of Medical Research | ||||
Article 52, Volume 30, Issue 4, October 2019, Page 330-335 PDF (276.65 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.221751 | ||||
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Authors | ||||
Mostafa A. El-Foly1; Lubna A. Fawaz2; Ashraf M. Osman3; Salwa H. Swelam4; Noura M. ElBakry4 | ||||
1Department of Pediatrics, Faculty of Medicine, Minia University, El Minya, Egypt | ||||
2Department of Pediatrics, Faculty of Medicine, Cairo University, Cairo, Egypt. | ||||
3Department of Clinical pathology, Faculty of Medicine, Minia University, El Minya, Egypt. | ||||
4Department of Pediatrics, Faculty of Medicine, Minia University, El Minya, Egypt. | ||||
Abstract | ||||
Background: Non-alcoholic fatty liver disease (NAFLD) it is one of the most common causes of liver disease worldwide. Visfatin is an adipocytokine hormone, which exerts an insulin-like effect by binding to the insulin receptor-1, we aim to investigate the correlation between serum Visfatin and NAFLD in Simple obese children. Methods: This prospective study included 62 children clinically evaluated as obese and 35 apparently healthy children, age and sex-matched as controls. Patients were recruited from the pediatric department of EL-Mina University, children's hospital. While controls were collected from healthy school children between September, 2016 and October, 2017. Fasting Visfatin, glucose, hemoglobinA1cand lipid levels were assayed and abdominal ultrasonography was done for detection of NAFLD. Results: There was a statistically significant correlation between serum Visfatin level and BMI (p<0.01), cholesterol levels (p< 0.01), triglycerides levels (p< 0.01), LDL levels (p< 0.01), HDL levels (p< 0.01) in both overweight and obese groups. Conclusions: Visfatin plays an important role in the pathogenesis of NAFLD. | ||||
Keywords | ||||
Non-alcoholic fatty liver disease; metabolic syndrome; Visfatin | ||||
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