ULTRASTRUCTURAL STUDY OF THE EFFECT OF CURCUMIN NANOPARTICLES ADMINISTRATION ON THE ALVEOLAR BONE STRUCTURE IN RATS WITH INDUCED PERIODONTITIS | ||||
| Alexandria Dental Journal | ||||
| Article 12, Volume 47, Issue 1, April 2022, Page 75-81 PDF (644.99 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/adjalexu.2021.71539.1183 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
mariam abdel aziz abu ayana  1; Hanaa mohamed Ali2; Khadiga yossef Kawana2; Rania abdelaziz Fahmy 3; Sara Ashraf Hamza4
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| 1Oral biology department faculty of dentistry alexandria university | ||||
| 2Professor, Department of Oral Biology, Faculty of Dentistry, Alexandria University, Egypt | ||||
| 3Assistant Professor, Oral Medicine and Periodontology, Faculty of Dentistry, Alexandria University, Alexandria City, Egypt | ||||
| 4lecturer of oral biology ,faculty of dentistry, Alexandria university, Alexandria, Egypt | ||||
| Abstract | ||||
| Background: Nowadays, the application of nanotechnology is recommended for potential treatments in dentistry. Curcumin nanoparticles (CURN) have been found to possess potential antioxidant and anti-inflammatory activities that can treat periodontitis which is considered as an inflammatory disorder that can spread down the gingiva causing alveolar bone destruction. Objectives: To evaluate the biological effect of CURN on alveolar bone structure in rats with ligature induced periodontitis. Materials and Methods: Thirty-five healthy adult male albino rats were divided into 3 groups: Group A (control group), Group B (periodontitis group) and Group C (curcumin nanoparticles treated group). A silk ligature was used to induce periodontitis in group B and C. After two weeks, the ligature was removed. CURN was then administrated orally to rats of group C (15 mg/kg/day). The animals were euthanized by the end of the experimental periods, after 2 and 4 weeks from removal of ligature. Right side mandibles were dissected out and prepared for scanning electron microscope (SEM) and energy dispersive x-ray microanalysis (EDX). Results: Scanning electron microscopic results revealed restoration of the alveolar bone level around mandibular first molar with decrease in the porosity in the surface of the alveolar bone in group C treated with CURN rather than in periodontitis group B. These results were confirmed by EDX which showed more calcium and less phosphorous percentage in group C than in group B. Conclusions: Curcumin nanoparticles have a positive biological effect on alveolar bone structure in rats with ligature induced periodontitis. Key words: Curcumin nanoparticles, anti-inflammatory, periodontitis | ||||
| Keywords | ||||
| Curcumin nanoparticles; anti-inflammatory; periodontitis | ||||
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