A romatase enzyme inhibitor versus gonadotropin for induction of ovulation in patients with polycystic ovary syndrome resistant to clomiphene citrate a randomized controlled trial | ||||
Minia Journal of Medical Research | ||||
Article 4, Volume 30, Issue 3, July 2019, Page 19-21 PDF (241.38 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.221848 | ||||
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Authors | ||||
Hossam Eldin Sh. Abd-Allah; Haitham A. Bahaa El-Din; Alaa G. Abd El-Azeem; Osama A. Abd El Aziz | ||||
Department of Obstetrics and Gynecology, El-Minia Faculty of Medicine | ||||
Abstract | ||||
Introduction: Clomiphene citrate (CC) is the first drug used to induce ovulation in patients with poly cystic ovary syndrome (PCOS). Although 70–80% of such women ovulate when treated with CC, only 40% become pregnant (van Wely et al., 2005). Women who do not ovulate with increasing doses of CC are CC-resistant (Amin et al., 2003). So a different modality of treatment for such patients was required. Aim of the work: The aim of the present work is to compare the effects of letrozole versus gonadotropin for induction of ovulation in patients with polycystic ovary syndrome resistant to clomiphene citrate. Patients and Methods: The present study is a randomized clinical trial. The study was conducted at infertility clinic of Minia general hospital, Minia, Egypt; throughout the duration of 18 months from January 2017 to June 2018. Results: Letrozole groups showed a statistically significant higher incidence of ovulation compared to gonadotropins group yet no difference in pregnancy rate was detected between the two groups. Discussion: Most studies comparing letrozole and gonadotropins in women with CC-resistant PCOS were either retrospective or in the context of intra uterine insemination presenting the need for studying letrozole versus gonadotropins in the context of induction of ovulation and timed intercourse. Summary: Letrozole is a cost effective modality for induction of ovulation in patients with PCOS resistant to CC. | ||||
Keywords | ||||
Clomiphene citrate; Aromatase enzyme; poly cystic ovary syndrome | ||||
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