A Review on Various Antioxidants Utilized in Bovine Semen Extenders

Abdel-Khalek, E.A., El-Nagar, H.A., and Omima M. Ibrahim., 2016. Effect of Leptin and Melatonin as protective additive to Tris extender on frozen semen quality of Buffalo Bulls. J. Animal and Poultry Prod., Mansoura Univ., 7(7): 225 – 231.

        DOI: 10.21608/JAPPMU.2016.48705

Ahmed, H., Jahan, S., Salman, M.M., and Ullah, F., 2019. Stimulating effects of Quercetin (QUE) in tris citric acid extender on post thaw quality and in vivo fertility of buffalo (Bubalusbubalis) bull spermatozoa.Theriogenology, 134:18–23.

         https://doi.org/10.1016/j.theriogenology.2019.05.012

Ahmed, H., Jahan, S., Ullah, H. Ullah, F. and Salman, M.M., 2020. The addition of resveratrol in tris citric acid extender ameliorates post-thaw quality parameters, antioxidant enzymes levels, and fertilizing capability of buffalo (Bubalus bubalis) bull spermatozoa. Theriogenology, 152:106–113.

https://doi.org/10.1016/j.theriogenology.2020.04.034

Ahmed, W.M., El-Tohamy, M.M., 1997.  Zinc profile in blood and semen of breeding buffalo-bull with particular emphasis on age variation and semen characteristics. In Proceedings of the 5th World Buffalo Congress, Royal Palace, Caserta, Italy, 13–16 October 1997.

 Aisen, E.G., Quintana, M., Medina, V., Morillo, H., and Venturino, A., 2005. Ultramicroscopic and biochemical changes in ram spermatozoa cryopreserved with trehalose based hypertonic extenders. Cryobiology, 50: 239-249. ISSN 1981-7223

Akhter, S., Rakha, B.A., Ansari, M.S.,  Andrabi, S.M.H., and Ullah. N., 2011. Storage of Nili-Ravi buffalo (Bubalus bubalis) semen in skim milk extender supplemented with ascorbic acid and α-tocopherol. Pak. J. Zool., 43: 273-277.  DOI:  0030-9923/2011/0002-0273 $ 8.00/0

Akhter, S., Rakha, B.A., Iqbal, R. N., and Ansari, M.S., 2014.  Effect of Bovine Serum Albumin on Motility, Plasmalemma, Viability and Chromatin Integrity of Buffalo Bull Spermatozoa. Pak. J. Zool., 46(1): 115-120. DOI: 0030-9923/2014/0001-0115 $ 8.00/0

Aljady, A.M., Kamaruddin, M.Y., Jamal, A.M., and Mohd Yassin, M.Y., 2010.  Biochemical study on the efficacy of Malaysian honey in infected wounds: An animal model. Med. J. Islam Acad. Sci.; 13(3): 125-132.

Amirat-Briand, L., Bencharif, D., Vera-Munoz, O., Bel Hadj Ali, H., Destrumelle, S., Desherces, S., Schmidt, E., Anton, M., and Tainturier, D.,  2009.   Effect of glutamine on postthaw motility of bull spermatozoa after association with LDL (low density lipoproteins) extender: preliminary results, Theriogenology, 71: 1209– 1214

.        DO10.1016/j.theriogenology.2008.10.002

Andrabi, S.M.H. 2009. Factors affecting the quality of cryopreserved buffalo (Bubalus bubalis) bull spermatozoa. Reprod. Domest. Anim., 44: 552-569. DOI: 10.1111/j.1439-0531.2008.01240.x

Andrabi, S.M.H., Ansari, M.S., Ullah, N., and Afzal, M., 2008. Effect of nonenzymatic antioxidants in extender on post-thaw quality of buffalo (bubalus bubalis) bull spermatozoa. Pak. Vet. J., 28(4): 159-162.

Ansari, M.S., Rakha, B.A., Ullah, N., Andrabi, S.M.H., Iqbal, S., Khalid, M., and Akhter, S.,2010. Effect of exogenous glutathione in extender on the freezability of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa. Anim. Sci. Pap. Rep., 28: 235-244. ISSN : 0860-4037

Ansari, M.S., Rakha, B.A., and Akhter, S., 2011. Effect of butylated hydroxytoluene in extender on motility, plasmalemma and viability of Sahiwal bull spermatozoa. Pak. J. Zool., 43: 311-314. DOI: 0030-9923/2011/0002-0311 $ 8.00/0

Ansari, M.S., Rakha, B.A., Ullah, N., Andrabi S.M.H., and Akhter, S., 2011a. Glutathione addition in tris-citric egg yolk extender improves the quality of cooled buffalo (Bubalus bubalis) bull semen. Pak. J. Zool., 43: 46-55. doi: 10.1016/j.repbio.2012.10.001.

Ansari, M.S., Rakha, B.A., Ullah, N., Andrabi, S.M.H., Khalid, M., and Akhter, S., 2011b. Effect of L-cysteine in tris-citric egg yolk extender on post thaw quality of Nili-Ravi buffalo (Bubalus bubalis) bull spermatozoa. Pak. J. Zool., 43: 41-47. DOI: 0030-9923/2011/0001-0041 $ 8.00/0

Ansari, M.S., Rakha, B.A., and Akhter, S.,  2011d. Effect of L-cysteine in extender on post-thaw quality of Sahiwal bull semen. Anim. Sci. Pap. Rep., 29: 197-203.

Ansari, M.S.,  Rakha, B.A., Andrabi, S.M.H., Ullah, N., Iqbal, R.,  Holt, W.V.  and Akhter, S., 2014. Thioglycol in extender improves the post-thaw quality of Buffalo (BUBALUS BUBALIS) Bull spermatozoa. J. Anim. Plant Sci. 24(4): 1256- 1259.  ISSN:1018-7081

Asadpour, R., Jafari, R.  and Nasrabadi, H.T., 2011. Influence of added vitamin C and vitamin E on frozen-thawed bovine sperm cryopreserved in citrate and Tris-based extenders. Vet. Res. Forum, 2: 37 – 44. ISSN : 2008-8140

Asadpour, R., Jafari, R., and Tayefi-Nasrabadi, H., 2011a. Effect of various levels of catalase antioxidant in semen extenders on lipid peroxidation and semen quality after the freeze-thawing bull semen. Vet. Res. Forum, 2(4): 218-221. ISSN : 2008-8140

Asadpour, R., Jafari, R., and Tayefi-Nasrabadi, H., 2012. The effect of antioxidant supplementation in semen extenders on semen quality and lipid peroxidation of chilled bull spermatozoa.  Iranian J. Vet. Res., 13 (3): 246– 249.

Asghari, M., and Hasanlooe, A.R. ,2015. Interaction effects of salicylic acid and methyl jasmonate on total antioxidant content, catalase and peroxidase enzymes activity in “Serosa” strawberry fruit during storage. Scientia Horti., 197: 490–495. https://doi.org/10.1016/j.scienta.2015.10.009  

Ashrafi, I., Kohram, H., and Ardabili, F.F., 2013.  Antioxidative effects of melatonin on kinetics, microscopic and oxidative parameters of cryopreserved bull spermatozoa. Anim. Reprod. Sci., 139: 25–30. DOI: 10.1016/j.anireprosci.2013.03.016

Badr, M. R., Mary, G., El-Malak, A., and Hassan, M.H., 2010. Effect of Trehalose on cryopreservation, oxidative stress and DNA integrity of buffalo spermatozoa. J. Reprod. Infertil., 1(2): 50-57. ISSn: 2079-2166.  

Badr, M., Rawash, Z., Azab, A., Dohreg, R., Ghattas, T., and Fathi, M., 2021. Spirulina platensis extract addition to semen extender enhances cryotolerance and fertilizing potentials of buffalo bull spermatozoa. Anim. Reprod., 18(2): 1-12. https://doi.org/10.1590/1984-3143-AR2020-0520

BADR, M.R., AZAB, A.M.S., and RAWASH, Z.M., 2014. Effect of Trehalose, Cysteine and Hypotaurine  on Buffalo Bull sperm freezaBility, ultrastructure changes  and fertilizing  poteNtials. Assiut Vet. Med. J., 60 (142).

Ball, B.A., Medina., V., Gravance, C.G., and Baumber, J., 2001. Effect of antioxidants on preservation of motility, viability and acrosomal integrity of Equine spermatozoa during storage at 5oC. Theriogenology, 56: 577-589. DOI: 10.1016/s0093-691x(01)00590-8

Bansal, A.K., and Bilaspuri, G.S., 2008.  Effect of manganese on bovine sperm motility, viability, and lipid peroxidation in vitro. Anim. Reprod., 5(3/4): 90-96.

Bath, M.L. 2010. Inhibition of in vitro fertilizing capacity of cryopreserved mouse sperm by factors released by damaged sperm, and stimulation by glutathione. PLoS One, 24: e9387.

         https://doi.org/10.1371/journal.pone.0009387

Beconi, M.T., Francia, C.R., Mora, N.G., and Affranchino.,  1993. Effect of natural antioxidant of frozen bovine semen preservation. Therio., 40:841-851. https://doi.org/10.1016/0093-691X(93)90219-U

Beheshti, R., Aiden Asadi, A.,  and Naser Maheri-Sis, N., 2011. The effect of vitamin E on post-thawed buffalo bull sperm parameters. J. American Sci., 7(6): 227-231. ISSN: 1545-1003). http://www.americanscience.org

Bilodeau, J.F., Blanchette, S., Gagnon, I.C., and Sirard, M.A.,  2001. Thiols prevent H2O2- mediated loss of sperm motility in cryopreserved bull semen, Theriogenology, 56: 275–286. DOI: 10.1016/s0093-691x(01)00562-3

Boots, A.W., Haenen, G.R., and Bast, A., 2008. Health effects of quercetin: from antioxidant to nutraceutical. Eur. J. Pharmacol., 585: 325–337. DOI: 10.1016/j.ejphar.2008.03.008

Bucak, M.N., Ataman, M.B., Baspinar, N., Uysal, O., Taspinar, M., Bilgili, A., Ozturk, C., Gungor, S., EInanc, M., and Akal, E., 2014. Lycopene and resveratrol improve postthaw bull sperm parameters: sperm motility, mitochondrial activity and DNA integrity. Andro., 47: 542-545. doi: 10.1111/and.12301

Bucak, M.N., Baspinar, N., Tuncer, P.B., Coyan, K., Sankozan, S., Akalin, P.P., and Kucukgunay, S. , 2012. Effects of curcumin and dithioerythritol on frozen-thawed bovine semen. Andro., 44: 102–109. doi: 10.1111/j.1439-0272.2010.01146.x

Bucak, M.N., Tuncer, P.B., Sarıozkan, S., Pınar, N.B.,  Pınar, M.T., Coyan, K., Bilgili, A., Akalın, P.P., and Buyukleblebici, S., 2010. Effects of antioxidants on post-thawed bovine sperm and oxidative stress parameters: Antioxidants protect DNA integrity against cryodamage. Cryobiology, 61: 248–253. doi:10.1016/j.cryobiol.2010.09.001

Chhillar, S., Singh, V.K., Kumar, R., and Atreja S.K., 2012. Effects of Taurine or Trehalose supplementation on functional competence of cryopreserved Karan Fries semen. Anim. Reprod. Sci., 135 (1-4):1-7.

         http://dx.doi.org/10.1016/j.anireprosci.2012.08.029

Chikhaliya P.S., Ahlawat, A.R., Singh, V.K., Vijyeta, H.P., Odedra, M.D., and Vala, K.B.,  2018. Effect of Different Concentrations of Taurine on Certain Biochemical Parameters During Cryopreservation of Gir Bull Semen. Int. J. Curr. Microbiol. App. Sci.,  7(7): 1441-1447. https://doi.org/10.20546/ijcmas.2018.707.171

Chuawongboon, P., Sirisathien, S., Pongpeng, J.  Sakhong D., nagai, T., and Vongpralub, T.,  2017. Effects of supplementation of iodixanol to semen extender on quality and fertilization ability of frozen–thawed Thai native bull sperm. Anim. Sci. J., 88: 1311–1320.  DOI: 10.1111/asj.12798 

Collodel, G., Federico, M.G., Geminiani, M., Martini, S., Bonechi, C., Rossi, C., Figura, N., and Moretti, E., 2011. Effect of transresveratrol on induced oxidative stress in human sperm and in rat germinal cells. Reprod. Toxicol. 31:239–246. DOI: 10.1016/j.reprotox.2010.11.010

Coyan, K., Bas¸ pınar, N., Bucak, M.N., Akalın, P.P., Ataman, M.B., Omur, A.D., Gungor, S.¸  Kucukgunay, S., Ozkalp, B., and Sarıozkan, S., 2010. Influence of methionine and dithioerythritol on sperm motility, lipid peroxidation and antioxidant capacities during liquid storage of ram semen. Res. Vet. Sci. 89:426–431. DOI: 10.1016/j.rvsc.2010.03.025

Daghigh-Kia H., Olfati-Karaji, R., Hoseinkhani, A., and Ashrafi, I., 2014. Effect of rosemary (Rosmarinus officinalis) extracts and glutathione antioxidants on bull semen quality after cryopreservation. Span. J. of Agri. Res., 12(1): 98-105. http://dx.doi.org/10.5424/sjar/2014121-4486

Daghigh-Kia, H., Farhadi, R., Ashrafi, I., and Mehdipour, M.^, 2016.  Anti‐oxidative Effects of Ethanol Extract of Origanum vulgare  on Kinetics, Microscopic and Oxidative Parameters  of Cryopreserved Holstein Bull Spermatozoa. Iran. J. of Appl. Anim. Sci., 6(4): 783-789.

Dorostkar K., Alavi-Shoushtari, S.M., and Mokarizadeh, A., 2012.  Effects of in vitro selenium addition to the semen extender on the spermatozoa characteristics before and after freezing in water buffaloes (Bubalus bubalis). Vet. Res. Forum,  3 (4):  263 – 268  PMCID: PMC4313046, PMID: 25653769

Dorostkar, K., Alavi Shoushtari, S.M., and Khaki, A.,  2014. Effects of in vitro zinc sulphate additive to the semen extender on water buffalo (bubalusbubalis) spermatozoa before and after freezing. Int. J. Ferti.  Steril., 8(3): 325-332. PMCID: PMC4221520, PMID: 25379162

Dowidar, Y.A., El-Nagar, H.A, El Refy, A.M. and Mousbah, A.M. 2018. Cryopreservation and Quality Assessment of Buffalo Bull (Bubalus bubalis) Semen Using New Moringa Extender and Antioxidant Co-Q10.   J. Anim. Poult. Prod., Mansoura Univ., 9: 375 – 381. DOI: 10.21608/JAPPMU.2018.41144

El-Nagar, H.A., EL Refy, A.M., A. M. and Mousbah, A.M., 2019. Freezing and Fertilizing abilities of Summer Semen of Egyptian buffalo (Bubalus bubalis) Bulls Using Moring Extract as Antibiotic or as a New Promising Extender.  J. Anim. and Poult. Prod., Mansoura Univ., 10 (3): 73 – 81. DOI: 10.21608/jappmu.2019.40527

El-Sheshtawy, R.I., and  El-Nattat, W.S., 2017. Effect of Diospyros kaki enriched extender on cattle bull sperm parameters and conception rate. Asian Pacific Journal of Reproduction; 6(3): 128-132.  DOI: 10.12980/apjr.6.20170306

El-Sheshtawy, R.I., and  El-Nattat, W.S., 2017a. Impact of silymarin enriched semen extender on bull sperm preservability. Asian Pacific Journal of Reproduction; 6(2): 81-84.  DOI: 10.12980/apjr.6.20170206

El-Sheshtawy, R.I., and El-Nattat, W.S., 2018.  Effect of tris-extender supplemented with various concentrations of strawberry (Fragaria spp.) on bull semen preservability. Asia. Paci. J. of Reprod., 7(2): 93-96.  doi: 10.4103/2305-0500.228019

El-Sheshtawy, R.I., El-Nattat, W.S., Ali, A.H., and Sabra, H.A., 2014a. The Effect of Phoenix dactylifera pollen grains tris-infusion on semen preservability of local bull breeds. Glob. Vet., 13(5): 728-732. DOI: 10.5829/idosi.gv.2014.13.05.86145

El-Sheshtawy, R.I., El-Nattat, W.S., and Ali, G.A., 2016. Preservability of Buffalo semen using tris-extender enriched with different concentrations of Strawberry.  Int. J. of Chem. Tech. Res., 9(6): 198-202.

El-Sheshtawy, R.I., El-Nattat, W.S., Sabra, H.A., and Ali, A.H., 2014b. Effect of Honey Solution on Semen Preservability of Local Breeds of Cattle Bulls. Wld. Appl. Sci. J., 32(10): 2076-2078.DOI: 10.5829/idosi.wasj.2014.32.10.911

El-Sheshtawy,R.I., El-Nattat, W.S., Shalaby, S.I.A., Shahba, M.I., and Al-Se'dawy, I.E., 2016a. Chilled and post-thawed semen characteristics of buffalo semen diluted in tris extender enriched with date palm pollen grains (TPG). Asia. Paci., J. of Reprod., 5(3): 252–255. DOI : 10.1016/j.apjr.2016.04.001

El-Sisy, G.A., El-Nattat, W.S., and El-Sheshtawy, R.I., 2008.  Effectof superoxide dismutase and catalase on viability of cryopreserved buffalo spermatozoa. Global Veterinaria, 2(2): 65–61. ISSN: 1992-6197 

El-Tantawy, W.H. 2016. Antioxidant effects of Spirulina supplement against lead acetate-induced hepatic injury in rats. J. Tradit. Complement. Med., 6: 327–331. DOI: 10.1016/j.jtcme.2015.02.001

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Fernandez-Santos, M.R., Dominguez-Rebolledo, A.E., Esteso, M.C., Garde, J.J., and Martinez-Pastor, F., 2009. Catalase supplementation on thawed bull spermatozoa abolishes the detrimental effect of oxidative stress on motility and DNA integrity. Int. J. Androl., 32: 353–359. DOI: 10.1111/j.1365-2605.2008.00871.x

Fu, J., Yang, Q., and Li, Y., 2018.  A mechanism by which Astragalus polysaccharide protects against ROS toxicity through inhibiting the protein dephosphorylation of boar sperm preserved at 4 degrees C. J.Cell Physiol., 233, 5267–5280. DOI: 10.1002/jcp.26321

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Granaci, V., 2007. Contributions on the study of the cryoresistance increase of the bull semen material. Bulletin of University of Agricultural Sciences and VeterinaryMedicine Cluj-Napoca. Anim. Sci. Biotechnol.,63/64:387–391.

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 Motemani, M., Chamani, M., Sharafi, M., and Masoudi, R., 2017.  Alpha-tocopherol improves frozen-thawed sperm quality by reducing hydrogen peroxide during cryopreservation of bull semen. Span. J., Agri. Res, 15(1): 7.

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Marqui, F.N., Martins, A., da Cruz, T.E., Berton, T.I.U. Dell’Aqua1, C.d.F., Júnior, J.A.D., and Oba, E.,  2018. Addition of iodixanol in bull freezing extender improves the sperm membranes integrity. Animal Reprod. Sci., 194:  26–27. https://doi.org/10.1016/j.anireprosci.2018.04.058

Martins, H.S., da Silva, G.C., Cortes, S.F., Paes, F.O., Martins Filho, O.A., Araujo, M., Stahlberg, R.,  and  Lagares, M.A., 2018. Lactoferrin increases sperm membrane functionality of frozen equine semen. Reprod. Domest. Anim., 53(3): 617-623. DOI: 10.1111/rda.13148

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