Resistin as an inflammatory marker in Lupus Nephritis | ||||
| Minia Journal of Medical Research | ||||
| Article 32, Volume 30, Issue 3, July 2019, Page 156-161 PDF (251.18 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221918 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Faten I. Mohamed1; Shimaa S. Ahmed1; Moustafa A. Abu El-Ella2; Maha A. Ali1 | ||||
| 1Department of Rheumatology and Rehabilitation, Faculty of Medicine, El-Minia University, | ||||
| 2Department of Clinical Pathology, Faculty of Medicine, El-Minia University, Egypt. | ||||
| Abstract | ||||
| Background: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that predominately affects women. It is characterized by a broad spectrum of clinical manifestations. Adipokines are a diverse family of soluble mediators with a range of specific actions on the immune response. Among the various adipokines is Resistin. Methods: 26 patients with lupus nephritis with age ranged between 18-48 years and 20 healthy age, sex and BMI matched individuals were enrolled in this study. Full history, clinical examination and laboratory investigations were performed for all patients including serum resistin level. Results: The level of serum resistin was higher in the patients than the controls (p < 0.001). Also, Serum resistin level correlated positively with the levels of ESR (p< 0.001), CRP (p= 0.008). Serum resistin levels correlated negatively with levels of C3 (p< 0.001) and C4 (p< 0.001). Conclusion: Serum resisitin level can be used as a marker of inflammation in patients with lupus nephritis. | ||||
| Keywords | ||||
| Systemic lupus erythematosus; lupus nephritis; adipokines; resistin. | ||||
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