Assessment of the Role of High Sensitivity C- Reactive Protein in Prediction of Immune Thrombocytopenia Response to Treatment by Steroids | ||||
| Minia Journal of Medical Research | ||||
| Article 53, Volume 30, Issue 3, July 2019, Page 249-252 PDF (337.81 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.221956 | ||||
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| Authors | ||||
| Mohammad E. AbdelFattah1; Alia A. Saad2; Aliaa S. Abd El-Fattah1; Fatma M. Mohammad1 | ||||
| 1Department of Internal medicine, Faculty of Medicine, Minia University, Egypt. | ||||
| 2Department of Internal medicine, Hematology unit, Faculty of Medicine, Cairo University, Egypt. | ||||
| Abstract | ||||
| Background: Nowadays, Primary Immune Thrombocytopenia diagnosis (ITP) is based on identifying a platelet count < 100 × 109 /L and exclusion of other causes of thrombocytopenia. Currently , there are no standard tests or biomarkers to diagnose primary ITP or predict its prognosis and response to treatment. Objectives :Our study aims at assessing the role of High sensitivity C- Reactive Protein in ITP pathogenesis and in the prediction of the disease behavior and response to treatment. Methods: Our study was done on four groups: Group I consisted of 28 newly diagnosed ITP patients in whom data were recorded before and after treatment with corticosteroids, Group II had 10 corticosteroid responder ITP patients, Group III contained 10 corticosteroid resistant ITP patients, while Group IV had 18 age and sex matched healthy control subjects to whom the previous three groups were compared. Results: Newly diagnosed ITP patients in our study were found to have significantly higher levels of High sensitivity CRP before treatment with corticosteroids compared to the same patients levels after treatment with corticosteroids, p value <0.001. Also, Comparing High sensitivity C- Reactive Protein levels in the four studied groups showed that they were higher in Corticosteroid resistant ITP patients (Group III) compared to the other three groups. p value <0.001. Conclusion: High sensitivity CRP level was found to be associated with ITP resistance to corticosteroid treatment, and it was found to decrease in the newly diagnosed patients after starting treatment by corticosteroids. | ||||
| Keywords | ||||
| Autoimmune; Immune thrombocytopenia; HSCRP; Resistant ITP; Corticosteroids | ||||
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