Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study
Amr, I., Abd El Hay, O., Hasan, M., Diab, M., Ibrahim, A., Taha, A., Elmetwally, S., Awad, M. (2022). Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study. EKB Journal Management System, 4(2), 2141-2148. doi: 10.21608/ijma.2022.221970
Ibrahim Mahrous Ibrahim Amr; Osama Mohammed Mohammed Abd El Hay; Mohamed Gaber Mohamed Hasan; Mahmoud Diab; Amal H. Ibrahim; Ahmed Mohammed Taha; Samir Atef Farid Elmetwally; Moaaz Moustafa Yousef Awad. "Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study". EKB Journal Management System, 4, 2, 2022, 2141-2148. doi: 10.21608/ijma.2022.221970
Amr, I., Abd El Hay, O., Hasan, M., Diab, M., Ibrahim, A., Taha, A., Elmetwally, S., Awad, M. (2022). 'Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study', EKB Journal Management System, 4(2), pp. 2141-2148. doi: 10.21608/ijma.2022.221970
Amr, I., Abd El Hay, O., Hasan, M., Diab, M., Ibrahim, A., Taha, A., Elmetwally, S., Awad, M. Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study. EKB Journal Management System, 2022; 4(2): 2141-2148. doi: 10.21608/ijma.2022.221970

Curcumin and Silymarin Amelioration of the Bisphenol-A induced Hepatotoxic Effects in Male Albino Rats: A structural, Biochemical and Molecular Experimental Study

International Journal of Medical Arts
Article 9, Volume 4, Issue 2, February 2022, Page 2141-2148  XML PDF (2.66 MB)
Document Type: Original Article
DOI: 10.21608/ijma.2022.221970
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Authors
Ibrahim Mahrous Ibrahim Amr email 1; Osama Mohammed Mohammed Abd El Hay email orcid 2; Mohamed Gaber Mohamed Hasan email 3; Mahmoud Diab email 4; Amal H. Ibrahim email 5; Ahmed Mohammed Taha email 6; Samir Atef Farid Elmetwally email 7; Moaaz Moustafa Yousef Awad email 8
1Department of Histology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
2Department of Physiology, Faculty of Medicine, Al-Azhar University, Egypt
3Department of Physiology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
4Department of Anatomy and Embryology, Faculty of Medicine, Al-Azhar University, Egypt
5Department of Internal Medicine, Faculty of Medicine for Girls, Al-Azhar University, Egypt
6Department of Pharmacology, Faculty of Medicine, Helwan University, Egypt
7Department of Forensic Medicine and Clinical Toxicology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
8Department of Anatomy and Embryology, Damietta Faculty of Medicine, Al-Azhar University, Egypt
Abstract
Background: Bisphenol A [BPA] is widely used in industrial processes. It persists in environment and exerts a harmful action on human health, through endocrine-disruption. Many natural compounds are suggested to have a preventive effect on BPA-induced human health hazards.
Aim of the work: This study aimed to evaluate the effect of Silymarin/Curcumin in ameliorating the hepatotoxic effect induced in albino rats following oral administration of BPA.
Patients and Methods: Fourty adult male albino rats were included and randomly categorized into four equal groups. The control group and BPA-exposed [50 mg/kg] group. Groups 3 and 4 for rats received oral BPA [50 mg/kg] plus [100 mg/ kg] of curcumin or silymarin. Serum liver enzymes, pro-inflammatory cytokines [TNF-α & IL-1,6,8] and the oxidant/antioxidant profile were assessed in the serum. SOD, GPX and CAT levels, MDA and H2O2 were assessed. Histopathological changes of the liver, immunohistochemical detection of caspase 3 and area density of collagen fibres were also assessed.
Results: Bisphenol-A administration for 30 days was associated with a significant increase in the number of pro-inflammatory markers as interleukin 1,6,8 and tumor necrosis factor‑α [TNF-α]. It also, stimulates oxidative stress with structural changes, apoptosis and fibrosis in hepatic cells. Treatment with curcumin or silymarin for 30 days lead to a reduction of pro‑inflammatory mediators and significant amelioration of structural changes.
Conclusion: Silymarin/Curcumin had an ameliorative of harmful effects of BPA on the liver cells through potent anti-inflammatory, antiapoptotic and antioxidant effects. 
Keywords
Bisphenol A; Liver, Oxidative stress; Hepatoprotective; Silymarin; Curcumin
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