Immunohistochemical Expression of Livin in Urinary Bladder Cancer | ||||
Minia Journal of Medical Research | ||||
Volume 30, Issue 2, April 2019, Page 40-43 PDF (280.37 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/mjmr.2022.221980 | ||||
View on SCiNiTO | ||||
Authors | ||||
Heba M. Tawfik1; Nehad M. Reda2; Manal A. Khalaf2; Alshaimaa W. Kasem1 | ||||
1Department of Pathology, Faculty of Medicine, Minia University, Egypt. | ||||
2Department of Pathology, Faculty of Medicine, Minia University, Egypt | ||||
Abstract | ||||
Background: Urinary bladder cancer (UBC), the most common urinary tract cancer and the ninth most common cancer worldwide. Livin is the most recently identified member of the inhibitor of apoptosis family. High expression levels of Livin may influence the prognosis of different types of cancer. The aim of current study is to investigate the relation between Livin expression and the clinicopathological features of UBC. Methods: Immunohistochemical staining for Livin was performed on 60 cases of urinary bladder cancer divided into; 43 cases of transitional cell carcinoma and 17 cases of squamous cell carcinoma. Results: As regarding transitional cell carcinoma, Livin high expression was detected in 48.8% of cases. A statistically significant association was observed between Livin high expression and higher tumor grade, advanced tumor stage (P value > 0.001, 0.001 respectively), larger tumor size and tumor multifocality (P value = 0.001, 0.035 respectively). As regarding squamous cell carcinoma, Livin high expression was detected in 52.9% of cases. A statistically significant association was observed between Livin high expression and higher tumor grade (P value > 0.001), advanced tumor stage, larger tumor size and tumor multifocality (P value = 0.018, 0.012, 0.019 respectively). Conclusion: Livin high expression could be considered as poor prognostic marker in the evaluation of patients with urinary bladder cancer, Livin can play essential role in the pathogenesis, aggressiveness, invasion, and progression of UBC. | ||||
Keywords | ||||
Immunohistochemistry; Livin; Transitional cell carcinoma; Squamous cell carcinoma. All authors have no conflict of interest | ||||
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