The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.
Bashandy, S., Abdelhameed, M., Farid, O., Morsy, F., Ibrahim, F., Elbaset, M. (2022). The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.. EKB Journal Management System, 65(10), 267-278. doi: 10.21608/ejchem.2022.115482.5242
Samir A Bashandy; Mohamed Fayed Abdelhameed; Omar Farid; Fatma Morsy; Fatma A. A. Ibrahim; Marawan Abd Elbaset. "The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.". EKB Journal Management System, 65, 10, 2022, 267-278. doi: 10.21608/ejchem.2022.115482.5242
Bashandy, S., Abdelhameed, M., Farid, O., Morsy, F., Ibrahim, F., Elbaset, M. (2022). 'The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.', EKB Journal Management System, 65(10), pp. 267-278. doi: 10.21608/ejchem.2022.115482.5242
Bashandy, S., Abdelhameed, M., Farid, O., Morsy, F., Ibrahim, F., Elbaset, M. The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.. EKB Journal Management System, 2022; 65(10): 267-278. doi: 10.21608/ejchem.2022.115482.5242

The Pivotal role of Cerium oxide nanoparticles in thioacetamide-induced hepatorenal injury in rat.

Egyptian Journal of Chemistry
Article 25, Volume 65, Issue 10, October 2022, Page 267-278  XML PDF (921.41 K)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.115482.5242
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Authors
Samir A Bashandy1; Mohamed Fayed Abdelhameed email orcid 2; Omar Faridorcid 3; Fatma Morsy4; Fatma A. A. Ibrahimorcid 5; Marawan Abd Elbasetorcid 6
1Pharmacology department, medical research and clinical studies, national research centre, Giza, Egypt.
2Pharmacology department, medical division, national research centre
3Researcher, National organization of drug control and research
4Department of Pathology, National Research Centre
5Biochemistry Dept, Biotechnology Institute, National Research Centre, 33 EL BohouthSt., Dokki, Cairo, Egypt
6Pharmacology Department, Medical Division, National Research Centre, Egypt, Cairo
Abstract
The objective of the present study is to investigate the protective effect of cerium oxide nanoparticles (15mg,30mg/kg) on hepatorenal injuries induced by thioacetamide (100mg/kg ). The size of cerium oxide nanoparticles (CeO2NPs) was 50nm. We evaluated the protective effect of CeO2NPs by studying their effect on oxidative stress, inflammatory markers, and histopathological changes in the liver and kidney. CeO2NPs improved antioxidant status in liver or kidney as manifested by enhancement of reduced glutathione (GSH) and a reduction in malondialdehyde (MDA), Nitic oxide (NO), and oxidized glutathione (GSSG). Also, CeO2NPs mitigated the decrease in plasma catalase (CAT), total antioxidant capacity (TAC), and hepatorenal ATP content resulting from thioacetamide (TAA). Moreover, the treatment of rats with CeO2NPs + TAA alleviated the significant increase in plasma liver enzymes (Gamma-glutamyltransferase (GGT), Aspartate aminotransferase (AST), Alanine aminotransferase (ALT), alkaline phosphatase(ALP)), kidney function parameters (Creatinine, urea, uric acid) and inflammatory markers (C-reactive protein (CRP), tumor necrosis factor-alpha(TNF-α), interleukin-6(IL-6)). The protective effect of ZnO-NPs was affirmed by histopathological study of the liver and kidney. Our results proposed that CeO2NPs may relieve TAA-hepatorenal toxicity via their antioxidant and anti-inflammatory properties that participated in the suppression of oxidative stress.
Keywords
cerium oxide nanoparticles; hepatorenal injuries; oxidative stress; inflammatory markers; histopathology
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