Potential anti-dyslipidemia and hepatoprotection of functional food components represented by tetracosanol and mixture of policosanol in Triton X-100 induced dyslipidemic rats | ||||
| Egyptian Journal of Chemistry | ||||
| Article 28, Volume 65, Issue 11, November 2022, Page 313-321 PDF (574.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.121634.5452 | ||||
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| Authors | ||||
Sahar Al-Okbi   1; Enas S.K. Al-Siedy 2
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| 1Department of nutrition and Food Sciences, National Research Centre, Cairo, Egypt | ||||
| 2Nutrition and Food Sciences Department, National Research Centre, Cairo, Egypt. | ||||
| Abstract | ||||
| The elevated plasma triglycerides (TGs), total cholesterol (TC) and low density lipoprotein-cholesterol (LDL-C) with concomitant reduction of high density lipoprotein-cholesterol (HDL-C) are designated as dyslipidemia. The aim of the present research was to study the protective effect of tetracosanol and policosanol mixture towards triton X-100 induced dyslipidemia along with their hepatoprotective effect in rats. The policosanol mixture was prepared from tetracosanol, hexacosanol, octacosanol and heptacosanol in the ratio of 3:1:1:1. Rats were divided into 4 groups; a normal control (NC), dyslipidemic control (DC) and two test groups with dyslipidemia and treated with either tetracosanol or policosanol mixture in the form of emulsions. The determined biochemical parameters were plasma TGs, TC, LDL-C, HDL-C, malondialdehyde (MDA) and the activities of alanine transaminase (ALT) and aspartate transaminase (AST). In addition to calculation of TC/HDL-C and LDL-C/HDL-C as the elevation of such ratios are considered risk factors for cardiovascular diseases (CVDs). Histopathological examination of liver was also carried out. Results showed significant dyslipidemia and elevated LDL-C/HDL-C, TC/HDL-C, MDA, ALT and AST with liver histopatological changes in the DC group compared to the NC group. Both tetracosanol and policosanol mixture reduced the risk factors for CVDs and improved the dyslipidemia, oxidative stress and liver function. Tetracosanol was superior in reducing TC, ALT and AST and improving liver histopathology while policosanol mixture was more efficient in reducing oxidative stress. | ||||
| Keywords | ||||
| Triton X-100; dyslipidemia; malondialdehyde; liver histopathology; tetracosanol; policosanol mixture; rats. | ||||
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