Hepatitis C Virus In Children In Beni –Suef Governorate
Abdel Megeed, A., Hodeeb, M., Ahmed, F. (2022). Hepatitis C Virus In Children In Beni –Suef Governorate. EKB Journal Management System, 3(1), 262-276. doi: 10.21608/ejmr.2022.222313
Abdel Megeed Aboul Magd Abdel Megeed; Mahmoud Mohamed Hodeeb; Fatma El Zahraa Saad Ahmed. "Hepatitis C Virus In Children In Beni –Suef Governorate". EKB Journal Management System, 3, 1, 2022, 262-276. doi: 10.21608/ejmr.2022.222313
Abdel Megeed, A., Hodeeb, M., Ahmed, F. (2022). 'Hepatitis C Virus In Children In Beni –Suef Governorate', EKB Journal Management System, 3(1), pp. 262-276. doi: 10.21608/ejmr.2022.222313
Abdel Megeed, A., Hodeeb, M., Ahmed, F. Hepatitis C Virus In Children In Beni –Suef Governorate. EKB Journal Management System, 2022; 3(1): 262-276. doi: 10.21608/ejmr.2022.222313

Hepatitis C Virus In Children In Beni –Suef Governorate

Egyptian Journal of Medical Research
Article 20, Volume 3, Issue 1, January 2022, Page 262-276  XML PDF (750.38 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.222313
View on SCiNiTO View on SCiNiTO
Authors
Abdel Megeed Aboul Magd Abdel Megeed; Mahmoud Mohamed Hodeeb; Fatma El Zahraa Saad Ahmed
Pediatrics department, Faculty Of Medicine,Beni- Suef University.
Abstract
The aim of this study is to study HCV infection in children in beni-suef governorate and to detect epidemiology and risk factors in studied group. HCV antibodies by4th generation ELISA. , alanine aminotransferase (ALT) levels and aspartate transaminase(AST) were done for children at the age of 6-17years . Every child with positive HCV antibodies was tested for HCV RNA by PCR. We studied 47 children positive for HCVantibody . 41 of them were HCV RNA positive and 6 of them had negative HCV RNA.Blood transfusion,frequent iv injection,hospitalization,previous operation,family history of HCV infection,circumcision and ear piercing are significant risk factors for infection.Pallor,jaundice and abdominal distention are common symptoms among HcvAb positive childrens. 100% of negative cases in HCV.Ab analysis were the same in PCR analysis in contrast from positive cases where 87% of positive cases in PCR agreed with HCV.Ab analysis but 13% of cases were negatively infected with HCV.ALT and AST were significantly higher in positive cases with HCVAb and PCR as compared to negative cases.
Keywords
Hepatitis C; Interferon; Children
References
  1. Thursz M, Fontanet A.HCV transmission in industrialized countries and resource-constrianed areas. Nat Rev Gastroenterol Hepatol.2014.11:28-35.11.
  2. Indolfi G, Azzari C, Resti M. perinatal transmission of hepatitis C virus. J Pediatr. 2013.163:1549-52.el
  3. YeungLT,Roberts EA. Current issues in the management of pediatric viral hepatitis. Liver Int. 2010Jan.30(1):5-18.
  4. PoordadF,McCone J Jr, Bacon BR, Bruno S, MannasMP,Sulkowski MS, et al.,Boceprevir for untreated chronic HCV genotype 1 infection N Engl J Med.2011Mar.364(13):1195-206.
  5. Bacon BR, Gordon SC, Lawitz E, Marcellin P, Vierling JM, Zeuzem S, et al. Boceprevir for previously treated chronic HCV genotype 1 infection.NEngl J Med. 2011 Mar.364(13):1207-17.        
  6. JonasMM, Balistereri W, Gonzalez-peraltaRP,Haber B, Lobritto S, Mohan P, et al., peginterferon for chronic hepatitis C in children affects growth and body composition: Results from the pediatric study of hepatitis  C (PEDS-C) Trial . Hepatology.2012 Mar. 28:1416-23.
  7. Arshad M, El-Kamary SS, Jhaveri R. "Hepatitis C virus infection during pregnancy and the newborn period – are they opportuntities for treatment ?".J.ViralHepat. 2011 April. 18(4):229-36.
  8. Balistreri WF, Murray KF, Rosenthal P, Bansal S, Lin CH, Kersey K, Massetto B, Zhu Y, Kanwar B, German P, et al. The safety and effectiveness of ledipasvir-sofosbuvir in adolescents 12-17 years old with hepatitis C virus genotype 1 infection. Hepatology. 2011;66:371–378.
  9. Wirth S, Rosenthal P, Gonzalez-Peraalta RP, Jonas MM, BalistreriWF,Lin CH, et al., Sofosbuvir and ribavirin in adolescents 12-17 years old with hepatitis C virus genotype 2 or 3 infection. Hepatology. 2017 May.22(52:501-7).
  10. Petruzziello A, Marigliano S, Loquercio G, Cozzolino A, CacciapuotiC.Global epidemiology of hepatitis C virus infection: An up‐date of the distribution and circulation of hepatitis C virus genotypes. World J Gastroenterol2016; 22: 7824‐7840.
  11. Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol.2014;61:S45–S57.
  12. Denniston MM, Jiles RB, Drobeniuc J, et al. Chronic hepatitis C virus infection in the United States, National Health and Nutrition Examination Survey 2003 to 2010. Ann Intern Med. 2014;160(5):293-300.
  13. Bakr I, Rekacewicz C, El Hosseiny M, et al.Higher clearance of hepatitis C virus infection in females compared with males. Gut 2006;5(8):1183-1187.
  14. Rushdy O, Moftah F, Zakareya S: Trasmitted transfused viral infections among blood donors during years 2006 and 2007 in suez canal area, Egypt. Vox Sang. 2009, 96: 86-87.
  15. Arthur RR, Hassan NF, Abdallah MY, El-Sharkawy MS, Saad MD, Hackbart BG, Imam IZ: Hepatitis C antibody prevalence in blood donors in different governorates in Egypt. Trans R Soc Trop Med Hyg. 1997, 91 (3): 271-274. 10.1016/S0035-9203(97)90070-5.
  16. Malu AO, Borodo MM, Ndububa DA, et al. Hepatitis B and C treatment guidelines for Nigeria, 2015. Niger J GastroenterolHepatol2015;7(2):63-75.
  17. Habib M, Mohamed MK, Abdel-Aziz F, Magder LS, Abdel-Hamid M, Gamil F, Madkour S, Mikhail NN, Anwar W, Strickland GT, et al. Hepatitis C virus infection in a community in the Nile Delta: risk factors for seropositivity. Hepatology. 2001;33:248–253.
  18. Medhat A, Shehata M, Magder LS, Mikhail N, Abdel-Baki L, Nafeh M, Abdel-Hamid M, Strickland GT, Fix AD: Hepatitis c in a community in Upper Egypt: risk factors for infection. Am J Trop Med Hyg. 2002, 66 (5): 633-638.
  19. Lu SN, Chen HC, Tang CM, Wu MH, Yu ML, Chuang WL, Lu CF, Chang WY, Chen CJ. Prevalence and manifestations of hepatitis C seropositivity in children in an endemic area. Pediatr Infect Dis J. 1998;17:142–145.
  20. Obienu O, Nwokediuko S, Malu A, et al. Risk factors for hepatitis C virus transmission obscure in Nigerian patients. Gastroenterol Res Pract2011(2011), article ID 939673
  21. Eita N: Prevalence of HCV and HBV infections among blood donors in Dakahilia, Egypt. Vox Sang. 2009, 96: 106-107.
  22. Morad WS: Transmission of hepatitis C between spouses an epidemiological study at National Liver Institute hospital. Int J Infect Dis. 2011, 15: S81
  23. Aceijas C, Friedman SR, Cooper HLF: Estimates of injecting drug users at the national and local level in developing and transitional countries, and gender and age distribution (vol 82, pg 10, 2006). Sex Transm Infect. 2006, 82 (4): 344-344.
  24. El-Zanaty F, Way A: Egypt Demographic and Health Survey 2008. Egyptian: Ministry of Health. 2009, Cairo: El-Zanaty and Associates, and Macro International.
  25. Saleh DA, Shebl FM, El-Kamary SS, Magder LS, Allam A, Abdel-Hamid M, Mikhail N, Hashem M, Sharaf S, Stoszek SK, et al: Incidence and risk factors for community-acquired hepatitis C infection from birth to 5 years of age in rural Egyptian children. Trans R Soc Trop Med Hyg. 2010, 104 (5): 357-363.
 

 

Statistics
Article View: 168
PDF Download: 103