A RETROSPECTIVE ANALYSIS OF EPIDEMIOLOGY AND CLINICAL OUTCOMES OF PATIENTS WITH ADULT GLIOMAS TREATED IN AIN SHAMS CLINICAL ONCOLOGY DEPARTMENT IN THE PERIOD FROM 2017 TILL 2020. | ||||
| Ain Shams Medical Journal | ||||
| Article 9, Volume 72, Issue 4, December 2021, Page 781-791 PDF (950.41 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/asmj.2021.222685 | ||||
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| Authors | ||||
| Hadeer Hesham Mohamed; Ghada Refaat Meckawy; Ahmed Said Ibrahim; Mai Ezz El Din; Lobna R. EZZ Elarab | ||||
| Department Of Clinical Oncology And Nuclear Medicine- Faculty Of Medicine - Ain Shams University, Egypt. | ||||
| Abstract | ||||
| Background: Gliomas are the most common malignant brain tumors in adults and comprise a wide array of varying biological aggressiveness. Though the data regarding the epidemiology of gliomas is presented in the literature, but they could vary according to other factors and consequently affecting the outcome. Aim of work: To analyse retrospectively epidemiological and clinical outcomes of adult glioma patients treated in Ain Shams University hospitals (ASU) in Cairo, Egypt in the period from 2017 till 2020. Patients and methods: Convenient sampling of 133 patients with adult brain glioma. The primary objective was to analyze the epidemiological and demographic data and to assess progression free survival (PFS) and overall survival (OS) of the study population. Secondary objectives included correlation between different clinic-pathological factors and outcome. Results: One hundred thirty-three participants were included, with a median age of 53, with a male to female ratio of 1.5. Incidence was more common in urban than rural areas (71.9 vs 28.1). Glioblastoma represented sixty percent of the cases, followed by grade II (22.7) then grade III (17.3%). The most common presenting symptom was focal deficits, followed by symptoms of increased intracranial tension. Percentage of patients who underwent maximum safe resection (MSR) was 19%, and 41.4% underwent subtotal excision. Almost eighty six percent of the patients received radiotherapy, while two-thirds of the patients received chemotherapy. PFS was significantly higher in patients offered MSR. OS was significantly higher with Grade II, MSR and better performance. Temporal lobe tumors have the best median OS. Conclusion: Progression free survival was significantly higher with initial MSR. Overall survival was significantly better with Grade II, MSR, better performance as well as temporal lobe tumors. Older age was significantly correlated with higher grade of gliomas. | ||||
| Keywords | ||||
| Glioma; epidemiology; risk factors | ||||
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