Serum Dickkopf-1 level in neonates with Hypoxic-Ischemic Encephalopathy | ||||
| Minia Journal of Medical Research | ||||
| Volume 30, Issue 1, March 2019, Page 62-65 PDF (232.37 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.222769 | ||||
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| Authors | ||||
| Mohamed F. Afifi1; Laila E. Aboul-Fotoh1; Mostafa A. El-Sayed Ahmed2; Mona M. Hassan3 | ||||
| 1Department of Pediatrics, Minia University, Minia, Egypt | ||||
| 2Department of Clinical Pathology, Minia University, Minia, Egypt | ||||
| 3Department of Clinical Pathology, Minia health insurance hospital, Minia, Egypt | ||||
| Abstract | ||||
| Objective: To measure the serum Dickkopf-1 level in neonates with HIE and to study its relation to the neurodevelopmental outcome in those neonates in comparison to healthy neonates. Methods: We measured serum levels of Dkk-1 by ELISA in neonates with HIE (n = 40) and in healthy controls (n = 30). Results: Dkk-1 serum levels increased significantly in HIE neonates than in healthy control, Serum DKK-1 levels increased significantly in severe HIE patients. Conclusion: DKK1 level was higher in neonates with HIE than normal neonates and DKK1 level correlated positively with the degree of HIE. | ||||
| Keywords | ||||
| Dickkopf-1; neonates; Hypoxic-Ischemic | ||||
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