CD19 and CD24 in beta thalassemia major and iron deficiency anemia in children | ||||
| Minia Journal of Medical Research | ||||
| Volume 30, Issue 1, March 2019, Page 140-142 PDF (133.57 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.222872 | ||||
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| Authors | ||||
| Hanan M. Kamel; Gehan . L Abdel Hakim; Nagwa I. Okaily Diab; Alaa A. Rashed | ||||
| Department of Clinical Pathology, El-Minia Faculty of Medicine | ||||
| Abstract | ||||
| Introduction: β-Thalassemia major is a hereditary hemolytic anemia caused by defect in β globin chain synthesis. Aim of the work: The aims of this study are: 1- Detection of CD19 and CD24 expression among children with β-thalassemia major and iron deficiency anemia. 2- The relationship of CD19 and CD24 to the clinical course of β-thalassemia major and iron deficiency anemia. 3- Correlation of CD19 and CD24 in β-thalassemia major and iron deficiency anemia. Subject and Methods: This prospective cohort study was conducted in the Department of Clinical pathology and Pediatric Hematology Unit at Minia University hospitals during the period from June 2017 to March 2018. This study included 60 patients in addition to 30 healthy controls, their age ranged from 9 months to 12 years. Results: Thirty beta thalassemia major children, thirty iron deficiency anemia children and thirty apparently healthy children as control, their age ranged from 9 months to 12 years. They were selected from out-patient clinics and those who were admitted in Pediatric department in Minia University hospital from June 2017 to March 2018. Discussion: β-thalassemia syndromes are the most common inherited hemoglobinopathies in the world caused by a genetic deficiency in βglobin chain synthesis. Summary: This study aimed to assess CD19 and CD24 expression in beta thalassemia major and iron deficiency anemia, and to evaluate their association with different demographic and laboratory data, as well as their relation to disease out come. | ||||
| Keywords | ||||
| BM: Bone marrow; AST: Aspartate transaminase; DB: Direct bilirubin | ||||
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