Outcome of Adjuvant 6 Cycles Chemotherapy versus 8 Cycles In Breast Cancer | ||||
| Minia Journal of Medical Research | ||||
| Volume 30, Issue 1, March 2019, Page 173-180 PDF (177.67 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.222883 | ||||
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| Authors | ||||
| El Sayed M. Ali; Emad Eldin N. Hassan; Heba A. Elsagheer Abdelal | ||||
| Clinical Oncology Department, Faculty of Medicine, Sohag University | ||||
| Abstract | ||||
| Background: Breast cancer is the most common site-specific cancer in women, the second most common cancer in the world, and is the leading cause of death from cancer for women aged 20 to 59 years. Aim of the study: To compare the results of disease-free survival (DFS), overall survival (OS), and toxicity level on both arms of patient who received 3 cycles of Anthracyclines followed by 3 cycles of Taxanes versus 4 cycles of Anthracyclines followed by 4 cycles of Taxanes. Patient and Method: A sample of 301 breast cancer patients of the oncology department of Suhag University Hospital, Suhag Cancer Center and clinical oncology clinic of Suhag Health Insurance participated in the study. Descriptive, significant tests and comparative statistical techniques were employed. Results: 62% of patients were postmenopausal and 37% premenopausal.50.8% of patients received 6 cycles chemotherapy and 49.2 % received 8 cycles Radiotherapy was administered to 99.3% patients and hormonal therapy was given to 87.4% patient. 18 cases of patients developed metastasis or locoregional recurrence. The 5yr OS of the whole patients is 92.2% and 91.9% for 6-cycles and 8- cycles arms respectively with no significant effect of the number of chemotherapy cycles on OS with P-value 0.5. The 5yr DFS of the whole cohort of patients is 96.1%, 91.1% respectively, for 6 and 8- cycles chemotherapy with no significant impact of the number of chemotherapy cycles and (P-value 0.2). Conclusion: Eight cycles (4 taxanes and 4 anthracyclines) is not superior to 6 cycles (3 taxanes and 3 anthracyclines) as there is no statistical significance between both arm with increased incidence of toxicity with longer treatment duration. | ||||
| Keywords | ||||
| breast cancer; chemotherapy toxicity; number of chemotherapy cycles; survival rate | ||||
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