Serum COLL2-1 In Rheumatoid Arthritis: Its Relation to Disease Activity and Severity | ||||
| Benha Medical Journal | ||||
| Article 17, Volume 39, Issue 1, March and April 2022, Page 235-246 PDF (603.36 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/bmfj.2021.90025.1456 | ||||
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| Authors | ||||
Samia Mohamed Abdel-Monem1; Amal Fathy Soliman2; Mohammed Moustafa Marei  3; Sania Khairy Elwia4; Rasha Mohamed Fawzy5
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| 1Department of Rheumatology @ Rehabilitation- Faculty of Medicine- Benha University | ||||
| 2Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Benha University, Egypt. | ||||
| 3Department of Rheumatology, Rehabilitation and Physical Medicine, Faculty of Medicine, Banha University, Egypt. | ||||
| 4Department of Biochemistry, Faculty of Medicine, Banha University, Egypt. | ||||
| 5Rheumatology, Rehabilitation & physical Medicine / Faculty of Medicine / Benha University / Benha / Egypt | ||||
| Abstract | ||||
| Abstract: Background: Rheumatoid arthritis is a chronic inflammatory disease characterized by proliferation of immunocompetent cells within synovial membranes. Type II collagen is the main protein component and specific for hyaline cartilage. Aim: This work aimed to measure serum level of Coll2-1, in RA patients ,study its association with disease activity and/or severity, and to determine its ability as a biomarker of the disease status. Patients and methods: This study was conducted on: Forty rheumatoid arthritis patients together with twenty primary knee OA patients and twenty volunteers as control groups. For RA patients; full history was obtained then clinical examination was performed. Disease activity. was assessed by DAS-28 and disease severity by Rheumatoid Arthritis Severity Scale (RASS). X- rays of both hands and feet graded by the Larsen score. Routine laboratory tests and serum Coll2-1 level was measured by ELISA. Results: Statistically significant increase in the mean serum Coll2-1 levels among RA and OA patients compared to the healthy controls (p= 0.001 each). No difference was found between RA and OA (p=0.14). Significant positive correlations (p < 0.05) between serum level of Coll2-1 in RA patients with patients’ ages, morning stiffness duration, tender and swollen joints number , ESR, CRP, DAS-28, radiological grading and RASS. Conclusion: This study highlighted the importance of Coll 2-1 biomarker reflecting disease activity and the destructive processes emerging in the joints of RA patients. It could be a promising tool in the pathogenesis of significant joint activity signaling cartilage and joint destruction. Key words: Coll2-1, Rheumatoid arthritis, Biomarkers. | ||||
| Keywords | ||||
| Coll2-1; Rheumatoid arthritis; Biomarkers | ||||
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