Quantitative EEG Spectral Power Ratio As Cognitive Biomarker For Patients With Parkinson Disease | ||||
Egyptian Journal of Medical Research | ||||
Article 24, Volume 3, Issue 1, January 2022, Page 313-322 PDF (370.4 K) | ||||
Document Type: Original Article | ||||
DOI: 10.21608/ejmr.2022.222940 | ||||
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Authors | ||||
Mostafa M. Elkholy 1; Hossam H Aboubakr2; Noha A. Abd ElMonem2; Rasha H Soliman2; Mohammed M. Masoud2 | ||||
1Department of Clinical Neurophysiology (Neuro-Diagnostic and Research Center), Faculty of Medicine, Beni-Suef University, Egypt | ||||
2Department of Neurology, Faculty of Medicine, Beni-Suef University, Egypt | ||||
Abstract | ||||
Background: Cognitive decline in patients with Parkinson disease (PD) is a major and progressing health problem that needs reliable and objective assessment tools. Aim: Toexplore the value of EEG spectral ratio as cognitive biomarker in patients with PD. Methods: This cross-sectional case control study enrolled 35 patients with PD and 20 matched healthy controls. All participants were evaluated by quantitative electroencephalography (EEG) spectral power ratio (slow/fast) over different head regions, in addition to clinical and neuropsychological assessment of the patients using Unified Parkinson’s Disease Rating Scale (UPDRS) and Montreal Cognitive Assessment (MoCA). Results: The UPDRS score of the patients was (mean 46.8 ± SD 26.6) and total MoCA score was (mean 20.3 ± SD 5.7). Twenty four of PD patients had cognitive impairment (MoCA <26) and showed significant higher spectral power ratio over the occipital region compared to PD patients with normal cognition (P=0.028). No significant differences of spectral power ratio between PD patients and controls. No significant correlation was found between power spectral ratio, UPDRS and MoCA scores. Conclusions: The occipital EEG spectral power ratio could be used as a complementary tool to neuropsychological assessment in evaluation and follow up of cognitive decline in patients with PD. | ||||
Keywords | ||||
Quantitative EEG; Spectral power ratio; Parkinson disease, Cognitive decline, Mild cognitive impairment | ||||
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