Role of third-trimester serum triglycerides in the prediction of large-for-gestational-age (LGA) in pregestational and gestational diabetes mellitus. | ||||
| Minia Journal of Medical Research | ||||
| Volume 30, Issue 1, March 2019, Page 258-266 PDF (282.17 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2022.223057 | ||||
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| Author | ||||
| Ahmed M. Farag | ||||
| Department of Obstetrics and Gynecology, Faculty of Medicine, Zagazig University, Egypt | ||||
| Abstract | ||||
| Introduction: Still there is increasing tendency to macrosomia in fetuses of diabetic women despite good diabetic control. Hyperglycemia is not only the responsible factor of undue fetal weight in pregnant women. The study intent was to find out whether maternal hyperlipidemia is responsible for prevalence of large for gestational age (LGA) in newborns of women with pregestational (PGDM) and gestational diabetes (GDM). Material and methods: This prospective observational, singlecenter study was executed in women with PGDM and GDM. Data were gathered in the (35th–38th weeks). Results: Among 216 pregnant women recruited in the analysis, 45 cases (20.8%) delivered average-for-gestational-age (AGA) newborns, all of them delivered normally. The remaining 171 cases (79.2%) newborns were large for gestational age (LGA), 100 of them were delivered by C.S and other 71 were delivered normally. The preponderance of LGA newborns was significantly higher in women with hypertriglyceridemia. Maternal TG and cholesterol levels were significantly higher in the group of LGA than in the AGA group (374.73±103.16) vs (242.23±88.99), p=0.00, and (249.93±38.85) vs (187.54±22.95), p <0.0001 respectively. While HDL was significantly lower in the LGA group than in the AGA group (53.95 ± 11.78) vs (66.61 ± 9.01), p <0.0001. Maternal Cholesterol, HDL and triglycerides levels tended to be correlated with newborn birth weight with sensitivity 80%, 86.7%, 86.7%, specificity 87.7%, 87.7%, 70.1% and cut off value >213.5mg/dl, <61.3mg/dl, >345mg/dl respectively. Conclusions: Decreased HDL and increased triglycerides levels in pregnant women with PGDM and GDM might chip in the evolution of fetal macrosomia or LGA. | ||||
| Keywords | ||||
| Pregestational and gestational diabetes; pregnancy; lipids; large-for-gestational-age | ||||
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