Synthesis & Biological Evaluation of Novel Series of Benzo[f]indazole Derivatives | ||||
| Egyptian Journal of Chemistry | ||||
| Article 27, Volume 65, Issue 11, November 2022, Page 305-312 PDF (551.95 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.120818.5418 | ||||
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| Authors | ||||
Ahmed M Hamdoon1; Mohanad Yakdhan Saleh   2; shakir M. Saied3
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| 1University of Mosul, College of Agriculture and Forestry, Branch of Basic Science | ||||
| 2Department of Chemistry, College of Education for pure science, University of Mosul | ||||
| 3Department of Medical Laboratory Techniques, Al-Noor University College, Mosul-Iraq | ||||
| Abstract | ||||
| A new series of benzo[f]indazole derivatives was synthesized via cyclo-condensation of β-ketoester with arylidenes derivatives in the presence of alcoholic sodium hydroxide to afford octahydronaphthalene-2-carboxylates. 1,3-Dipolar cycloaddition between these carboxylates and hydrazine hydrate to form benzo[f]indazole derivatives. New obtained compounds were characterized upon elemental and spectroscopic analyses. Antibacterial activity of selected derivatives was evaluated. | ||||
| Keywords | ||||
| Benzo[f]indazole; Biological Evaluation; Chalgone; β- keto ester | ||||
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