An Insight of Oxybutynin in Hyperhidrosis: Mechanism of Action and Efficacy; Review Article | ||||
| The Egyptian Journal of Hospital Medicine | ||||
| Article 31, Volume 87, Issue 1, April 2022, Page 1162-1164 PDF (414.38 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejhm.2022.223151 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Mai Ali Othman  ; Samia Ali Ebrahim; Basma Magdy Elkholy
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| Abstract | ||||
| Background: For those with hyperhidrosis, the condition can cause psychological and social distress. Moreover, hyperhidrosis in certain sites as the palms can cause significant physical and occupational disability. Aluminum chloride, iontophoresis, sympathectomy botulinum toxin injections as well as oxybutynin have all been examined in the therapy of hyperhidrosis. As of yet, the perfect modality has not been discovered. In the absence of unambiguous data supporting one way over the other, selecting between multiple methods remains a clinical problem. In 1988, oxybutynin was linked to hyperhidrosis as an antimuscarinic medication. Individuals with primary severe hyperhidrosis or elderly patients who aren't eligible for surgery are increasingly turning to this medicine as an initial or alternate treatment. Objective: Assessment of hyperhidrosis treatment effectiveness by oxybutynin and overview of its mechanism. Methods: The databases were searched for articles published in English in 4 databases. PubMed, Google scholar, science direct, and Boolean operators (and or not) had been used such as oxybutynin chloride, hyperhidrosis, or hyperhidrosis treatment and in peer-reviewed articles between January 2005 and August 2021. Conclusion: Oxybutynin chloride has been effectively used in the treatment of hyperhidrosis at different sites. It acts by inhibiting the muscarinic action of acetylcholine. Despite its satisfactory results, the treatment is associated with multiple side effects due to its anticholinergic action in the form of dry mouth, urinary retention, constipation, and headache. In addition, the majority of patients are unable to take it because of the lengthy daily administration schedule. | ||||
| Keywords | ||||
| Oxybutynin chloride; Hyperhidrosis | ||||
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