Use of Letrozole Pretreatment with Misoprostol for Induction of Abortion in First Trimester : A Randomized Controlled Trial | ||||
| Evidence Based Women's Health Journal | ||||
| Article 15, Volume 12, Issue 1, February 2022, Page 125-132 PDF (1.44 MB) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ebwhj.2021.112340.1163 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Amr Nadim1; Reda Ghanem2; Shereen Rady  1
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| 1Obstetrics and gynecology Ain shams university Cairo Egypt | ||||
| 2Obstetrics and gynecology faculty of medicine Ain shams university | ||||
| Abstract | ||||
| Aim: This study aimed to compare the efficacy of using letrozole pretreatment before misoprostol versus using misoprostol alone for the medical termination of first trimester missed abortion. Materials and Methods: This clinical trial was conducted at Ain-Shams University Maternity Hospital in the period between January 2020 and August 2020, and was registered at clinical trials.gov Identifier. NCT04590482. Patients that seem to be fulfilling the inclusion criteria were recruited, then, an informed written consent was taken from every patient before starting the examination. Followed by detailed history and examination of all the patients. Hemoglobin, hematocrit, blood group, RH, and trans- vaginal ultrasound were done for all patients before the study. Results: The result of the study demonstrated an increase in complete abortion rate (primary outcome) at day 3 in group A (56.6%) more than group B (35.2%) which was statistically significant. Also there was an increase in the incidence of complete abortion at day 7 in group A (77.4%) more than group B (68.5%) but with no statistically significant difference between the two groups. Conclusion: Using of letrozole pretreatment with misoprostol for induction of first trimester abortion is better than using of misoprostol alone, as there was an increase in complete abortion rate in group A more than group B. | ||||
| Keywords | ||||
| Abortion; letrozole; misoprostol | ||||
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