Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study
Alagizy, H., Aiad, H., Abdel-Wahed, M., Elshenawy, M., Abou-Sheishai, H., El-Rebey, H. (2022). Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study. EKB Journal Management System, 87(1), 1216-1225. doi: 10.21608/ejhm.2022.223165
Hagar A. Alagizy; Hayam Abdel-Samie Aiad; Moshira Mohamed Abdel-Wahed; Mahmoud Abdelsattar Elshenawy; Heba Gaber Abou-Sheishai; Hala Said El-Rebey. "Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study". EKB Journal Management System, 87, 1, 2022, 1216-1225. doi: 10.21608/ejhm.2022.223165
Alagizy, H., Aiad, H., Abdel-Wahed, M., Elshenawy, M., Abou-Sheishai, H., El-Rebey, H. (2022). 'Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study', EKB Journal Management System, 87(1), pp. 1216-1225. doi: 10.21608/ejhm.2022.223165
Alagizy, H., Aiad, H., Abdel-Wahed, M., Elshenawy, M., Abou-Sheishai, H., El-Rebey, H. Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study. EKB Journal Management System, 2022; 87(1): 1216-1225. doi: 10.21608/ejhm.2022.223165

Expression of Tumor infiltrating Lymphocytes (Tils), Forkhead Box P3 (FOXP3) and Cyclooxygenase-2 (COX2) in Breast Cancer Patient’s Tumor Tissue, A Single Institute Study

The Egyptian Journal of Hospital Medicine
Article 39, Volume 87, Issue 1, April 2022, Page 1216-1225  XML PDF (688.03 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2022.223165
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Authors
Hagar A. Alagizy email ; Hayam Abdel-Samie Aiad; Moshira Mohamed Abdel-Wahed; Mahmoud Abdelsattar Elshenawy; Heba Gaber Abou-Sheishai; Hala Said El-Rebey
Abstract
Background: Breast cancer (BC) is the most common cancer worldwide and is the main cause of cancer related death in women. Forkhead boxp3(FOXP3) is a transcription factor that plays an important role in the development and function of immune regulatory T cells (Tregs). A strong relation between the COX-2/PGE2 pathway and FOXP3-positive Tregs has been proposed.
Objective: We implemented this study to evaluate the prognostic significance of FOXP3 and COX-2 expression and relation with overall survival in BC patients.
Patients and Methods: This study was conducted on archival cases of 66 BC patients. Tumor infiltrating lymphocytes was evaluated in H&E slides whether peri-tumoral or intra-tumoral and were classified as absent, low, moderate, and high infiltration. Sections from each case were stained for FOXP3 and Cyclo-oxygenase 2(COX2). Expression of FOXP3 was assessed in malignant epithelial tissues and in tumor infiltrating lymphocytes (intra-tumoral and peri-tumoral). Expression of COX-2 was assigned in tumor epithelial cells and correlated with overall survival.
Results: Higher FOXP3 H. scores in epithelial cells were associated with younger age, low grade tumors, non-triple negative group. Higher FOXP3 H. scores in peri-tumoral lymphocytes were significantly associated with young age. Higher H. scores of COX2 expression was associated with PR negative cases. OS was improved in patients with high infiltration by peri-tumoral infiltrating lymphocytes and high FOXP3 positive intra-tumoral lymphocytes scores.
Conclusions: Dense TILs as well as high FOXP3 expression are considered as good prognostic factors. On the other hand, COX2 might be considered to have poor prognostic role.
 

 
 
 
Keywords
Tumor Infiltrating Lymphocytes; FOXP3; COX2; Immunohistochemical Expression; Breast Cancer
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