Study Of Role Of Lipoxin – A4 In Psoriasis
Al Nemr, H., El-Rifaie, A., Nagib, R., Rashed, L. (2022). Study Of Role Of Lipoxin – A4 In Psoriasis. EKB Journal Management System, 3(1), 334-344. doi: 10.21608/ejmr.2022.223174
Hanan Abo Zaid Mohamed Al Nemr; Abd El Aziz El-Rifaie; Rehab Mohamed Nagib; Laila Ahmed Rashed. "Study Of Role Of Lipoxin – A4 In Psoriasis". EKB Journal Management System, 3, 1, 2022, 334-344. doi: 10.21608/ejmr.2022.223174
Al Nemr, H., El-Rifaie, A., Nagib, R., Rashed, L. (2022). 'Study Of Role Of Lipoxin – A4 In Psoriasis', EKB Journal Management System, 3(1), pp. 334-344. doi: 10.21608/ejmr.2022.223174
Al Nemr, H., El-Rifaie, A., Nagib, R., Rashed, L. Study Of Role Of Lipoxin – A4 In Psoriasis. EKB Journal Management System, 2022; 3(1): 334-344. doi: 10.21608/ejmr.2022.223174

Study Of Role Of Lipoxin – A4 In Psoriasis

Egyptian Journal of Medical Research
Article 26, Volume 3, Issue 1, January 2022, Page 334-344  XML PDF (500.6 K)
Document Type: Original Article
DOI: 10.21608/ejmr.2022.223174
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Authors
Hanan Abo Zaid Mohamed Al Nemr1; Abd El Aziz El-Rifaie1; Rehab Mohamed Nagib1; Laila Ahmed Rashed2
1Dermatology and Andrology department, Faculty of Medicine, Beni-Suef University, Egypt.
2Biochemistery department, Faculty of Medicine ,Cairo University, Egypt.
Abstract
The aim of this work was to evaluate the level of lipoxin – A4 (LXA4) in patients  with psoriasis and its correlation with clinical parameters. This study included 25 psoriatic patients who were recruited from the outpatient clinics of dermatology department, Faculty of Medicine, Beni-Suef University. In addition, 25 age and sex-matched volunteers were included as control group. Four mm punch skin biopsy will be taken from the tissue and will be kept in lysis solution for the stability of the studied parameters and will be kept frozen at -80°C till detection of LXA4 in tissue by real time-PCR. Peripheral blood samples for serum LXA4 are taken. Blood samples will be centrifuged and serum will be stored at 80°C and used for ELISA. The LPXA levels in the case ranged from 1.01 -7.8 ng/mL with a mean of 2.94 ±1.7 ng/mL. In addition, the LXA4 levels in the control ranged from 4.5 – 14.7 ng/mL with a mean of 9.45 ±2.26 ng/mL. The level of LXA4 is significantly downregulated in patients with psoriasis, compared to healthy volunteers. Moreover, the affection of LXA4 appears to be correlated with the severity of the diseases. LXA4 and its analogue may be potential therapeutic candidates for psoriasis.
Keywords
Psoriasis; LXA4; LXA4 analogue
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