Characterization of Dry Powder Inhaler Quercetin Solid Lipid Microparticle (SLM) as Lung Delivery System: Effect of Polymer Concentration | ||||
| Egyptian Journal of Chemistry | ||||
| Article 24, Volume 65, Issue 11, November 2022, Page 281-289 PDF (530.2 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.120170.5393 | ||||
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| Authors | ||||
DEWI MELANI HARIYADI   1; Iqlima Prestisya2; Gatot Suhariyono3; Andangndang Miatmoko2; Noorma Rosita4; Mahardian Rahmadi2
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| 1Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Campus C Jl. Mulyorejo Surabaya, Indonesia | ||||
| 2Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo | ||||
| 3Pusat Teknologi Keselamatan dan Metrologi Radiasi – BATAN, Indonesia | ||||
| 4Faculty of Pharmacy Universitas Airlangga, Campus C Jl. Mulyorejo Campus C Jl. Mulyorejo | ||||
| Abstract | ||||
| The inhalation route for pulmonary treatment can provide many advantages such as high surface area with fast absorption due to high vascularity, avoiding the first pass effect, therapeutic effect can be achieved at much lower doses, as well as targeted drug delivery so as to reduce side effects. Solid lipid microparticle system containing Quercetin which was formed as Dry Powder using glyceryl behenate as lipid and poloxamer 188 as surfactant polymer was prepared. The system was characterised in terms of moisture content, morphology, particle size, flow properties, aerosolization study, mass median aero dynamic (MMAD) and in vitro release. Size and morphology was spherical and smooth with dry and small size met inhalation size ( | ||||
| Keywords | ||||
| SLM; Quercetin; Inhalation; Lung Disease; Poloxamer 188 | ||||
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