The Association between Anti-Histone and Anti-Vimentine autoantibodies with Peripheral Neuropathy in Systemic Lupus Erythematous | ||||
| Benha Journal of Applied Sciences | ||||
| Article 16, Volume 7, Issue 2, February 2022, Page 115-119 PDF (532.29 K) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2022.223945 | ||||
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| Authors | ||||
| G.A. Hammad1; S.A. Egila1; N.H. Ibrahim1; N.A. Badran1; R.A. El Sayed2 | ||||
| 1Rheumatology, Rehabilitation and Physical medicine, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt | ||||
| 2Medical Biochemistry, Dept., Faculty of Medicine, Benha Univ., Benha, Egypt. | ||||
| Abstract | ||||
| Systemic lupus erythematosus (SLE) is a systemic, chronic disease characterized by a persistent immune hyperactivation response with multiorgan destruction, accompanied with various autoantibodies. Peripheral neuropathy is an important manifestation of SLE. Antibodies to histones (AHA) are commonly seen in SLE patients. Vimentin is a protein of intermediate filament family, which is expressed in all mesenchymal cells. Aim of work: The aim of the study was to correlate between the peripheral neuropathy and the disease activity and severity and to determine the association between anti-histone and anti-vimentin IGg autoantibodies levels and peripheral neuropathy in SLE patients. Patients and methods: This study was a case control study that included fifty patients diagnosed according to SLICC 2019 criteria for SLE and thirty apparently healthy volunteers recruited as a control group. Assessment of damage was done by SLICC/ACR damage index. Serum level of Ig G autoantibodies against: heparin sulfate, Histone H2B and Vimentin was assessed by ELISA. Electrodiagnostic studies were done to median nerve, ulnar nerve, radial nerve, tibial nerve, peroneal and sural nerve. Results: The vast majority of cases were females, with only 6% males and the mean age of the study population was 23 years. As regard the immunological characteristics, nearly all of the cases had positive ANA (96%), while only around 78% had positive anti double stranded DNA. Anti-vimentin was positive in only 18% of the cases. Anti-histone was positive in 28% of the case. SLEDAI score showed positive non-significant correlations with each of anti-vimentin and anti-histone. Conclusion: Positive and significant correlations could be found between peripheral neuropathy in SLE patients and levels each of anti-vimentin and anti-histone. Non-significant correlations could be found between severity of SLE and each of anti-vimentin and anti-histone anti bodies . | ||||
| Keywords | ||||
| vimentin; histone; Systemic Lupus Erythematous | ||||
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