THE POTENTIAL PROTECTIVE EFFECT OF FOLIC ACID AGAINST BISPHENOL A-INDUCED TOXICITY IN PREGNANT MICE AND THEIR FETUSES | ||||
| Egyptian Journal of Zoology | ||||
| Article 9, Volume 68, Issue 68, December 2017, Page 163-180 | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.12816/0043186 | ||||
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| Authors | ||||
Hend Mohammed  1; Hanan A. Okail2
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| 1Department of Zoology, Faculty of Science, Ain Shams University, Cairo, Egypt | ||||
| 2Department of Zoology, Faculty of Science, Sohag University, Sohag, Egypt | ||||
| Abstract | ||||
| This study aimed to examine the protective effect of folic acid (FA) against bisphenol A (BPA)-induced toxicity through the hematological and biochemical parameters of pregnant mice as well as the histological and immunohistochemical alterations in the liver of pregnant mice and their fetuses. A total of 30 Albino pregnant mice were divided into three groups of 10 mice each. The first group was kept as a control. The second group was administered orally by 5 mg/kg of BPA from day 1 to 18 of gestation. The third group was administered orally by 5 mg/kg of BPA concurrently with intraperitoneal (ip) injection of FA 100 mg/kg daily from day 1 to 18 of gestation. However, BPA-treated pregnant mice showed a significant reduction in red blood cell (RBC) count, blood hemoglobin (Hb) content, hematocrit value (Ht), and white blood cell (WBC) count. Also, the serum activity of aspartate amino transferase (AST) and alanine amino transferase (ALT) levels were elevated. Treatment of pregnant mice with BPA followed by FA restored RBCs, Hb, Ht and WBCs values to nearly normal and resulted in a significant reduction in the serum activities of AST and ALT. Sever histopathological changes were observed with a significant increase in caspase-3 production in liver tissues of BPA-treated pregnant mice and their fetuses, and the FA treatment succeeded to minimize these changes with a decrease in caspase-3 production as compared to the liver of BPA-treated group. In conclusion, folic acid treatment has a protective effect and was able to reduce the negative impacts of bisphenol A-induced toxicity in pregnant mice and their fetuses. | ||||
| Keywords | ||||
| bisphenol A; Folic acid; hematology; histopathology; liver enzymes; apoptosis | ||||
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