Stromal Myofibroblast Density in Dentigerous Cyst, Odontogenic Keratocysts and Ameloblastoma: An Immunohistochemical Study | ||||
| Ain Shams Dental Journal | ||||
| Article 10, Volume 22, Issue 2, June 2021, Page 70-76 PDF (877.71 K) | ||||
| Document Type: Original articles | ||||
| DOI: 10.21608/asdj.2021.69669.1036 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
Ebthal Ahmed Marzuk   ; Nermeen Sami Afifi ; Houry Moustafa Baghdadi
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| oral pathology, faculty of dentistry, ASU, cairo, egypt | ||||
| Abstract | ||||
| Abstract Aims and objectives: This study aimed to analyze immunohistochemically the density of myofibroblast (MF) in dentigerous cyst (DC), odontogenic keratocyst (OKC) and ameloblastoma (AB). Methods: Thirty formalin-fixed, paraffin-embedded specimens of DC, OKC and AB, ten each, were included in the present study. Immunohistochemical staining with anti-α-SMA primary antibody was performed. Area fraction of immunopositivity was measured by image analysis software followed by statistical analysis using Kruskal Wallis followed by post-hoc Dunn’s. Results: All cases of the three lesions were immunopositive for α-SMA. The median area fractions were 0.57, 8.72 and 17.87 for DC, OKC and AB respectively with a statistically non-significant difference between AB and OKC and statistically significant differences between AB and DC and between OKC and DC. A positive correlation was observed between the density of MF and the known biologic behavior of the lesions. Conclusion: Over-expression of α-SMA found in AB and OKC might be used as a reliable marker for aggressiveness. | ||||
| Keywords | ||||
| Keywords: ameloblastoma; dentigerous cyst; odontogenic keratocysts; myofibroblast | ||||
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