Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children
Atallah, R., Amer, A., Abd El-Samee, H., Ibraheem, R. (2019). Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children. EKB Journal Management System, 74(1), 156-161. doi: 10.21608/ejhm.2019.22645
Rabie Bedir Atallah; Ahmed Wahhed-Allah Amer; Hesham Samir Abd El-Samee; Reham Mahmoud Ibraheem. "Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children". EKB Journal Management System, 74, 1, 2019, 156-161. doi: 10.21608/ejhm.2019.22645
Atallah, R., Amer, A., Abd El-Samee, H., Ibraheem, R. (2019). 'Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children', EKB Journal Management System, 74(1), pp. 156-161. doi: 10.21608/ejhm.2019.22645
Atallah, R., Amer, A., Abd El-Samee, H., Ibraheem, R. Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children. EKB Journal Management System, 2019; 74(1): 156-161. doi: 10.21608/ejhm.2019.22645

Correlation between Serum Interleukin-31 Level and the Severity of Atopic Dermatitis in Children

The Egyptian Journal of Hospital Medicine
Article 23, Volume 74, Issue 1, January 2019, Page 156-161  XML PDF (292.05 K)
Document Type: Original Article
DOI: 10.21608/ejhm.2019.22645
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Authors
Rabie Bedir Atallah1; Ahmed Wahhed-Allah Amer1; Hesham Samir Abd El-Samee2; Reham Mahmoud Ibraheem email 3
1Departments of Dermatology, Venereology & Andrology
2Clinical pathology, New Damietta Faculty of Medicine, Al-Azhar University, Damietta
3Departments of Dermatology, Desouk General Hospital, Egypt
Abstract
Background: Atopic dermatitis (AD) is a chronic inflammatory skin disease, characterized by intense itch, typical localization and a specific image of skin lesions. Pathogenesis of pruritus in AD is not fully understood, but recent studies emphasize the role of interleukin-31 (IL-31). This relatively recently described cytokine is considered to be a potential mediator inducing pruritus in AD. Aim of the Work: was to assess the correlation of serum IL-31 level and the disease severity in children with AD. Patients and Methods: a case control study. Sera were obtained from 50 AD children and 30 healthy volunteers. IL-31 levels were measured using ELISA with standard kits from EIAab R&D Systems. Serum IL-31 levels were correlated with AD disease activity. Disease severity in children with AD was assessed using the SCORAD (Severity scoringof atopic dermatitis) index. Results: Serum IL-31 level was significantly higher in AD children (Mean ± SD 99.73 ± 75.93) than in healthy children (Mean ± SD 54.01 ± 57.36), (p-value = 0.019). Serum IL-31 levels correlated positively with the calculated severity score (SCORAD index), (rs = 0.480, p- value <0.001) Conclusion: The results of this study confirm the importance of IL-31 in AD pathophysiology. Serum IL-31 level is an objective reliable marker of AD severity in children. It may represent a novel target for antipruritic drug development.
Keywords
atopic dermatitis; interleukin-31; severity SCORAD; pruritus; children
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