Synthesis and biological activity evaluation of some novel heterocyclic compounds incorporating pyridine / chromene moiety | ||||
| Egyptian Journal of Chemistry | ||||
| Article 51, Volume 65, Issue 12, December 2022, Page 569-576 PDF (700.54 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/ejchem.2022.127181.5653 | ||||
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| Authors | ||||
Fathy Mohamed Abdel-Razek  1; Ali M. S. Hebishy2; Rewaida H. Ali2
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| 1Chemistry Department, Faculty of Science, Cairo University, Giza 12613, Egypt | ||||
| 2Chemistry Department, Faculty of Science, Helwan University, Helwan, Egypt | ||||
| Abstract | ||||
| 4-Bromoacetyl pyridine 2a and 3-bromoacetylcoumarine 2b react with malononitrile 3 and thiourea 6 to afford the furan and the thiazole derivatives 5a,b and 7a,b respectively. The thiazoles 7a,b react with DMFDMA 8, phenyl isothiocyanate 10, acetic anhydride 12 and ethyl cyanoacetate 14 to afford the thiazole derivatives 9-13a,b and the thiazolo[3,2-a]pyrimidinone derivatives 16a,b respectively. All structures are proven by analysis and spectral methods. The biological activity of the synthesized compounds was screened as anti bacterial and anti fungal agents. | ||||
| Keywords | ||||
| Acetyl pyridine; acetyl coumarine; Furans; thiazoles; thiazolo[3; 2-a]pyrimidine derivatives | ||||
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