Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.
Ashry, M., Mustafa, M., Mourad, H., EL-Kassaby, M., Morsy, F., N., S., Abdel-Wahhab, K. (2018). Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.. EKB Journal Management System, 10(2), 45-61. doi: 10.21608/eajbsc.2018.22667
Mahmoud Ashry; Mohamed A. Mustafa; Hagar H. Mourad; Mahitab I. EL-Kassaby; Fatma Adly Morsy; Sayed O. N.; Khaled G. Abdel-Wahhab. "Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.". EKB Journal Management System, 10, 2, 2018, 45-61. doi: 10.21608/eajbsc.2018.22667
Ashry, M., Mustafa, M., Mourad, H., EL-Kassaby, M., Morsy, F., N., S., Abdel-Wahhab, K. (2018). 'Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.', EKB Journal Management System, 10(2), pp. 45-61. doi: 10.21608/eajbsc.2018.22667
Ashry, M., Mustafa, M., Mourad, H., EL-Kassaby, M., Morsy, F., N., S., Abdel-Wahhab, K. Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.. EKB Journal Management System, 2018; 10(2): 45-61. doi: 10.21608/eajbsc.2018.22667

Anti-nephrotoxic and Antioxidant Efficiency of Rosmarinus Officinalis Extract Against Isoniazid®-Induced Nephropathy in Adult Male Albino Rats.

Egyptian Academic Journal of Biological Sciences. C, Physiology and Molecular Biology
Article 5, Volume 10, Issue 2, December 2018, Page 45-61  XML PDF (972.94 K)
Document Type: Original Article
DOI: 10.21608/eajbsc.2018.22667
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Authors
Mahmoud Ashry1; Mohamed A. Mustafa2; Hagar H. Mourad3; Mahitab I. EL-Kassaby3; Fatma Adly Morsy4; Sayed O. N.5; Khaled G. Abdel-Wahhab3
1Zoology Department, Faculty of Science, Al-Azhar University, Egypt
2Basic Centre of Science, Misr University for Science and Technology, Egypt
3Medical Physiology Department, National Research Centre, Egypt
4Pathology Department, National Research Centre, Egypt
5Chemistry Department, Fayoum University, Cairo, Egypt
Abstract
Tuberculosis accounted as a serious disease throughout the world, and nephrotoxicityis one of the most serious side effects of main anti-tuberculosis drugs. The objective of this study was to explore the nephro-protective potential of rosemary aqueous extract against Isoniazid®-induced nephrotoxicity. Adult male Wistar albino rats (150-170g) were randomly divided into four groups: 1) normal rats, 2) rats administrated with rosemary extract (440mg/kg/day), 3) rats received Isoniazid® (50mg/kg/day), and 4) rats treated with Isoniazid® in combination with rosemary extract. After eight weeks, the results revealed that rosemary extract along with Isoniazid® minimized the Isoniazid®-induced renal deterioration; this was evidenced by the significant reduction in serum levels of urea, creatinine, uric acid, TNF-α, IL-1β and Na+ as well as kidney MDA, nitric oxide and DNA fragmentation .This was matched with  a marked enhancement in calcium and K+ serum levels. and so kidney GSH, and Na+/K+ ATPase activity. Moreover, the histopathological findings showed a potential protection as the extract succeeded in prevention of Isoniazid® induced tissue degenerations. In conclusion, rosemary extract could play a beneficial role for the prevention of Isoniazid®-nephrotoxicity via its anti-oxidative and anti-nitrosative voltage.
Keywords
tuberculosis; Isoniazid® (INH); Nephrotoxicity; rosemary; Rats
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