Diagnostic value of MR spectroscopy in suspicious breast lesions

Hasan, Nahla Mohamed Ali; Hussein, Mohamed Mamdouh Noaman; Abdelrazek, Naglaa Mohamed; Soliman, Mohamed Tharwat Mahmoud

doi:10.21608/svuijm.2022.125320.1289

	Diagnostic value of MR spectroscopy in suspicious breast lesions
SVU-International Journal of Medical Sciences
Article 13, Volume 5, Issue 2, July 2022, Page 115-135 PDF (715.93 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2022.125320.1289
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Authors
Nahla Mohamed Ali Hasan ¹; Mohamed Mamdouh Noaman Hussein¹; Naglaa Mohamed Abdelrazek²; Mohamed Tharwat Mahmoud Soliman¹
¹Diagnostic Radiology Department, Faculty of Medicine, Sohag University, Sohag, Egypt.
²Diagnostic Radiology department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Abstract
Background: MRI has an essential role in breast imaging, along with mammography and ultrasonography. DCE- MRI is not 100% accurate in discriminating benign from malignant lesions. In attempt to improve the specificity of DCE-MRI, multiparametric MRI (mp-MRI) with additional functional parameters had been introduced. Objectives: To assess the added diagnostic value of MR spectroscopy in evaluation of suspicious breast lesions. Patients and methods: This prospective study included 60 females, their mean age was 42.1 ± 12 SD with 75 breast lesions categorized as BI-RADS 3 or BI-RADS 4 based on sonomamography. They were subjected to multiparametric breast MRI (T2WI, dynamic contrast-enhanced MR imaging, diffusion-weighted images, and MR spectroscopy). ROC-analysis was employed for comparison between the diagnostic accuracy of mp-MRI and mp-MRI combined with MRS to predict the malignant lesions using the histopathological results as a standard of reference. Results: 33 (55 %) patients had histopathologically diagnosed 43 (58%) benign breast lesions and 27 (45%) patients had 32 (42%) malignant lesions. Using mp-MRI (dynamic contrast-enhanced MR imaging, T2-weighted images and diffusion-weighted images) had 98% accuracy of with 97.8%, sensitivity and 98.6%, specificity in differentiating malignant from benign lesions. A higher diagnostic 99.2% accuracy was obtained from combined mp-MRI and MRS with 99.5% sensitivity, 98.6% specificity. Conclusion: Despite of its limitations, MRS is a promising functional MRI technique thus improves the diagnostic accuracy of MRI for characterization of suspicious breast lesions when combined to mp-MRI to avoid unnecessary biopsy.
Keywords
Breast lesions; mp-MRI; MR Spectroscopy


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