Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)
Flaviano, J., Kenniker, M., Ganda, F., Sacedor, J., Lee, M., Cabuhat, K. (2018). Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio). EKB Journal Management System, 10(2), 53-60. doi: 10.21608/eajbsz.2018.22733
J. F. Flaviano; M. A. A. Kenniker; F. J. C. Ganda; J. Sacedor; M. Y. S. Lee; K. S. P. Cabuhat. "Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)". EKB Journal Management System, 10, 2, 2018, 53-60. doi: 10.21608/eajbsz.2018.22733
Flaviano, J., Kenniker, M., Ganda, F., Sacedor, J., Lee, M., Cabuhat, K. (2018). 'Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)', EKB Journal Management System, 10(2), pp. 53-60. doi: 10.21608/eajbsz.2018.22733
Flaviano, J., Kenniker, M., Ganda, F., Sacedor, J., Lee, M., Cabuhat, K. Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio). EKB Journal Management System, 2018; 10(2): 53-60. doi: 10.21608/eajbsz.2018.22733

Assessment of the Toxic and Teratogenic Effects of Kamagong (Diospyros discolor Willd.) Leaves Extract to the Developing Embryo of Zebrafish (Danio rerio)

Egyptian Academic Journal of Biological Sciences, B. Zoology
Article 5, Volume 10, Issue 2, December 2018, Page 53-60  XML PDF (553.5 K)
Document Type: Original Article
DOI: 10.21608/eajbsz.2018.22733
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Authors
J. F. Flaviano1; M. A. A. Kenniker1; F. J. C. Ganda1; J. Sacedor1; M. Y. S. Lee2; K. S. P. Cabuhat3
1Assemblywoman Felicita G. Bernardino Memorial Trade School, Lias Marilao, Bilacan, Philippines
2Department of Biology, College of Science, Bulacan State University, City of Malolos, Bulacan, Philippines
3AD-Drugstel Pharmaceutical Laboratories Inc., First Bulacan Industrial City, Tikay Malolos, Bulacan, Philippines
Abstract
This work highlighted the embryo-toxic and teratogenic effects of D. discolor leaves extract to the embryo of D. rerio, a model. Apparently, 100% mortality of embryos was observed in 5% and 10% treatment concentration at 12 hpta. Meanwhile, mortality in lower concentrations increases as time of exposure is prolonged and as the amount of treatment concentration increases. Coagulation was the toxic effect of the plant water extract. On the other hand, heartbeat and hatchability rate decreases as the amount of treatment concentration increases. In terms of teratogenicity, tail malformation was the most marked teratogenic effect of the plant extract. Moreover, growth retardation, head malformation, yolk deformities and abdominal edema were observed. Altogether, D. discolor leaves water extract exhibit toxic and teratogenic effects against D. rerio embryo. Thus, this plant contains active phytochemical components that can be developed as anticancer drugs.
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