PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY
Essa, D., Omar, O., Elhemaly, A., Wassef, N. (2022). PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY. EKB Journal Management System, 68(2), 1171-1181. doi: 10.21608/edj.2022.111020.1909
Dina Essa; Ola Omar; Ahmed Elhemaly; Nada Wassef. "PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY". EKB Journal Management System, 68, 2, 2022, 1171-1181. doi: 10.21608/edj.2022.111020.1909
Essa, D., Omar, O., Elhemaly, A., Wassef, N. (2022). 'PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY', EKB Journal Management System, 68(2), pp. 1171-1181. doi: 10.21608/edj.2022.111020.1909
Essa, D., Omar, O., Elhemaly, A., Wassef, N. PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY. EKB Journal Management System, 2022; 68(2): 1171-1181. doi: 10.21608/edj.2022.111020.1909

PREVENTION OF ORAL MUCOSITIS USING CHAMOMILE ORAL CRYOTHERAPY VERSUS ORAL CRYOTHERAPY IN PEDIATRIC CANCER PATIENTS RECEIVING CHEMOTHERAPY: A RANDOMIZED PILOT STUDY

Egyptian Dental Journal
Article 6, Volume 68, Issue 2 - Serial Number 1, April 2022, Page 1171-1181  XML PDF (338.62 K)
Document Type: Original Article
DOI: 10.21608/edj.2022.111020.1909
View on SCiNiTO View on SCiNiTO
Authors
Dina Essa email 1; Ola Omar2; Ahmed Elhemaly3; Nada Wassef4
1Post Graduate Student, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, Egypt
2Professor, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, Egypt
3Assistant Professor, Paediatric Oncology Department, National Cancer Institute, Cairo University, Egypt
4Associate Professor, Pediatric Dentistry and Dental Public Health Department, Faculty of Dentistry, Cairo University, Egypt
Abstract
Objective: To assess the prevention of oral mucositis using chamomile oral cryotherapy versus oral cryotherapy in pediatric cancer patients receiving chemotherapy.
Methods: The study included participants aged 6 to 18 years diagnosed with osteosarcoma undergoing chemotherapy (Methotrexate), with intact oral mucosa, and no history of administration of any antiviral or antifungal therapy for oral mucositis. The study population consisted of 20 patients and was divided equally into two groups; (Group A) using the chamomile oral cryotherapy and (Group B) using oral cryotherapy. Oral mucosa was evaluated at baseline, 8th, 15th and 21st day using the Children International Mucositis Evaluation Scale (ChIMES) and the World Health Organization Oral Mucositis Toxicity Scale (WHO mucositis scale).
Results: For the patient reported oral mucositis, the total ChIMES score was higher in patients in group B on all evaluation times with a median and range values of [0(0-1) for baseline, 6(2-12) for day 8, 7.5(4-12) for day 15 and 2(1-6) for day 21]. According to WHO mucositis scale, patients in chamomile oral cryotherapy group never developed grade 2 or higher mucositis with a statistically significant difference found between both groups at day 15 (80% grade 2 in control group versus 0% in chamomile group).
Conclusions: Chamomile oral cryotherapy showed better results in reducing the incidence and severity of chemotherapy-induced oral mucositis in comparison to oral cryotherapy.
Keywords
oral mucositis; cancer; pediatric oncology; stomatitis; bone tumors
Statistics
Article View: 238
PDF Download: 1,499