In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens
Malki, F., Touati, A. (2019). In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens. EKB Journal Management System, 3(1), 281-285. doi: 10.21608/nrmj.2019.28114
Fatiha Malki; Abdelkader Touati. "In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens". EKB Journal Management System, 3, 1, 2019, 281-285. doi: 10.21608/nrmj.2019.28114
Malki, F., Touati, A. (2019). 'In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens', EKB Journal Management System, 3(1), pp. 281-285. doi: 10.21608/nrmj.2019.28114
Malki, F., Touati, A. In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens. EKB Journal Management System, 2019; 3(1): 281-285. doi: 10.21608/nrmj.2019.28114

In vitro inhibitory potential of two synthesized fatty amides derivatives against some microbial pathogens

Novel Research in Microbiology Journal
Volume 3, Issue 1, January and February 2019, Page 281-285  XML PDF (196.73 K)
Document Type: Original Article
DOI: 10.21608/nrmj.2019.28114
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Authors
Fatiha Malki email ; Abdelkader Touati
Laboratoire De Recherche Sur Les Produits Bioactifs Et Valorisation De La Biomasse, Ecole Normale Supérieure, 16308,BP 92, Kouba, Algiers, Algeria
Abstract
In the present study, two amide derivatives with long chains; N-cyclohexyloctamide 1 and N-Phenyldodecanamide (dodecanilide) 2 were synthesized. They were tested in vitro for a wide array of antimicrobial activities against; two Gram positive bacteria (Bacillus subtilis, Staphylococcus aureus), four Gram negative bacteria (Escherichia coli, Pseudomonas aeruginosa, Klebsiella pneumoniae, Salmonella enteric), and three fungi (Aspergillus carbonarius, Mucor ramannianus, Candida albicans), to evaluate their potential use as antimicrobial agents. Zones of inhibition of these compounds were determined by disc diffusion assay. Results revealed high antimicrobial activities of the two amides. The new fatty N-cyclohexyloctamide 1 showed significant antimicrobial activity against S. aureus and A. carbonarius, and was more active against C. albicans than synthesized fatty anilide 2, as it caused higher zones of inhibition. On the other hand, the fatty anilide 2 demonstrated high antibacterial activity against P. aeruginosa, and was more active against S. enteric than substituted fatty amide 1. On the basis of these obtained results, it could be assumed that fatty amide derivatives may be used as components of disinfectants, and may be possible sources of new drugs effective against various infectious diseases.
Keywords
Amide derivatives; Synthesis; Antimicrobial activity; Disk diffusion assay
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