Antitumor efficacy of biosynthesized manganese nanoparticles
Abuheiba, E., M. El-Sonbaty, S., Abdel-Samed, N., Kandil, E. (2019). Antitumor efficacy of biosynthesized manganese nanoparticles. EKB Journal Management System, 3(3), 387-395. doi: 10.21608/nrmj.2019.37212
Eman Abuheiba; Sawsan M. El-Sonbaty; Nahed Abdel-Samed; Eman Kandil. "Antitumor efficacy of biosynthesized manganese nanoparticles". EKB Journal Management System, 3, 3, 2019, 387-395. doi: 10.21608/nrmj.2019.37212
Abuheiba, E., M. El-Sonbaty, S., Abdel-Samed, N., Kandil, E. (2019). 'Antitumor efficacy of biosynthesized manganese nanoparticles', EKB Journal Management System, 3(3), pp. 387-395. doi: 10.21608/nrmj.2019.37212
Abuheiba, E., M. El-Sonbaty, S., Abdel-Samed, N., Kandil, E. Antitumor efficacy of biosynthesized manganese nanoparticles. EKB Journal Management System, 2019; 3(3): 387-395. doi: 10.21608/nrmj.2019.37212

Antitumor efficacy of biosynthesized manganese nanoparticles

Novel Research in Microbiology Journal
Volume 3, Issue 3, May and June 2019, Page 387-395  XML PDF (266.61 K)
Document Type: Original Article
DOI: 10.21608/nrmj.2019.37212
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Authors
Eman Abuheiba email 1; Sawsan M. El-Sonbaty2; Nahed Abdel-Samed3; Eman Kandil1
1Biochemistry Department, Faculty of Science, Ain Shams University, Cairo, Egypt
2Radiation Microbiology Department, National Center for Radiation Research and Technology; Egyptian Atomic Energy Authority, Cairo, Egypt
3Physiology Research Department, National Center for Radiation Research and Technology, Egyptian Atomic Energy Authority, Cairo, Egypt
Abstract
This study aimed to evaluate the in vitro and in vivo antitumor potential of manganese nanoparticles, in management of hepatocellular carcinoma (HCC) induced in rats. Manganese nanoparticles were biosynthesized using Lactobacillus helveticus cells.  In vitro study of manganese nanoparticles on HepG-2 (human cell line of a well-differentiated HCC) revealed an IC50 of 21.5 mM.  The in vivo efficacy of manganese nanoparticles was evaluated by measuring the antioxidant activities against oxidative stress caused by diethylnitrosamine (DEN) in rates liver tissues. This treatment significantly improved  the alanine aminotransferase (ALT) activity  and  total protein compared to DEN group. Results showed that manganese nanoparticles were effective in treatment of HCC induced by diethylnitrosamine (DEN) in rats. So manganese nanoparticles can serve as a good therapeutic agent for the treatment of hepatocellular carcinoma, and deserve further studies in the future.
Keywords
Hepatocellular carcinoma; Diethylnitrosamine; Manganese nanoparticles; Antitumor potential
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