The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation
A. Elbadri, S., S. Fathi, M., E. Abdel Hamid, A., A. ElGendy, H. (2019). The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation. EKB Journal Management System, 3(4), 428-439. doi: 10.21608/nrmj.2019.44951
Shaimaa A. Elbadri; Marwa S. Fathi; Amira E. Abdel Hamid; Hanaa A. ElGendy. "The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation". EKB Journal Management System, 3, 4, 2019, 428-439. doi: 10.21608/nrmj.2019.44951
A. Elbadri, S., S. Fathi, M., E. Abdel Hamid, A., A. ElGendy, H. (2019). 'The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation', EKB Journal Management System, 3(4), pp. 428-439. doi: 10.21608/nrmj.2019.44951
A. Elbadri, S., S. Fathi, M., E. Abdel Hamid, A., A. ElGendy, H. The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation. EKB Journal Management System, 2019; 3(4): 428-439. doi: 10.21608/nrmj.2019.44951

The effect of Lactobacillus acidophilus as a probiotic against Pseudomonas aeruginosa growth and biofilm formation

Novel Research in Microbiology Journal
Volume 3, Issue 4, July and August 2019, Page 428-439  XML PDF (464.18 K)
Document Type: Original Article
DOI: 10.21608/nrmj.2019.44951
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Authors
Shaimaa A. Elbadri email orcid 1; Marwa S. Fathi1; Amira E. Abdel Hamid1; Hanaa A. ElGendy2
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Ain Shams University, Cairo, Egypt
2Department of Anesthesia, Intensive Care and Pain Management, Faculty of Medicine, Ain Shams university, Cairo, Egypt
Abstract
The emergence of antibiotic-resistant biofilm producing microorganisms such as Pseudomonas aeruginosa has pushed efforts to find safe alternatives to antibiotics; such as probiotics. Lactobacilli are one of these promising probiotics, with reported antibacterial and anti-biofilm activity against many different pathogenic microorganisms. This study aimed to study the potential antibacterial and anti-biofilm effect of Lactobacillus acidophilus ATCC 4356, against the growth and biofilm formation of pathogenic P. aeruginosa. Cell free supernatant of L. acidophilus was tested to inhibit the growth; biofilm formation, and on preformed biofilms by 35 different clinical strains of P. aeruginosa, using agar well diffusion and microtitre plate assays. L. acidophilus ATCC 4356 recorded powerful growth inhibition against 88.6% of the P. aeruginosa strains. Moreover; it significantly inhibited biofilm formation of the strains by 68.52%, and removed already preformed biofilms with 43.8 % activity. Finally; L. acidophilus showed a potent inhibitory potential against the growth and biofilm formation by P. aeruginosa strains, thus could be used as a powerful probiotic for the bio-control of infections caused by antibiotic resistant and biofilm producing P. aeruginosa.
Keywords
Lactobacillus acidophilus; Probiotics; Pseudomonas aeruginosa; Biofilm
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