Fluoroquinolone Mannich bases as promising biologically beneficial molecules | ||||
| Minia Journal of Medical Research | ||||
| Volume 32, Issue 2, April 2021, Page 21-35 PDF (356.21 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/mjmr.2021.228161 | ||||
 View on SCiNiTO | ||||
| Authors | ||||
| Islam M. Abdel-Rahman1; Mohamed Abdel-Aziz2; Alaa Hayallah3; Gamal El-Din A. Abuo-Rahma2 | ||||
| 1Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Deraya University, 61519-New Minia, Minia, Egypt. | ||||
| 2Department of Medicinal Chemistry, Faculty of Pharmacy, Minia University | ||||
| 3Department of pharmaceutical Organic Chemistry, Faculty of Pharmacy, Assiut University, Assiut | ||||
| Abstract | ||||
| Mannich bases, a structurally heterogeneous aminomethyl functionality, found numerous applications in medicinal chemistry field. Fluoroquinolones-Mannich bases here is discussed, with prominence on the correlation between structure and biological activity as it could be responsible for enhancing physicochemical properties of fluoroquinolones. The review covers broadly the literature works that correlated fluoroquinolones-Mannich bases cytotoxicity activity as anticancer agents rather than their antibacterial activity. The most applicable studies on the activity of fluoroquinolones-Mannich bases as potential antimycobacterial candidates and antiviral agents have been included as well. This contemporary review considers a first kernel for upcoming exertions in designing and synthesis of more Fluoroquinolone -Mannich bases. | ||||
| Keywords | ||||
| Fluoroquinolones; Mannich bases; Antibacterial; Anticancer; Antimycobacterial | ||||
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