Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.
Taha, R., El-Fakharany, E., El-Shafiey, Z., Salman, A., Mansour, M., Yahia, M. (2023). Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.. EKB Journal Management System, 66(1), 387-398. doi: 10.21608/ejchem.2022.117920.5313
Rania H. Taha; Esmail El-Fakharany; Zienab El-Shafiey; Aida Salman; Mai Mansour; Mohamed Yahia. "Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.". EKB Journal Management System, 66, 1, 2023, 387-398. doi: 10.21608/ejchem.2022.117920.5313
Taha, R., El-Fakharany, E., El-Shafiey, Z., Salman, A., Mansour, M., Yahia, M. (2023). 'Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.', EKB Journal Management System, 66(1), pp. 387-398. doi: 10.21608/ejchem.2022.117920.5313
Taha, R., El-Fakharany, E., El-Shafiey, Z., Salman, A., Mansour, M., Yahia, M. Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.. EKB Journal Management System, 2023; 66(1): 387-398. doi: 10.21608/ejchem.2022.117920.5313

Synthesis and physicochemical characterization of Schiff base complexes and examination of their selectivity index for breast and colon cancer cells.

Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 387-398  XML PDF (1.23 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.117920.5313
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Authors
Rania H. Taha1; Esmail El-Fakharanyorcid 2; Zienab El-Shafiey1; Aida Salman1; Mai Mansour1; Mohamed Yahia email orcid 3
1Department of Chemistry, Faculty of Science (Girls), Al-Azhar University, P.O. Box: 11754, Yousef Abbas Str., Nasr City, Cairo, Egypt.
2Protein Research Department, Genetic Engineering and Biotechnology Research Institute (GEBRI), City of Scientific Research & Technological Applications (SRTA-City), New Borg El-Arab City, P.O. Box: 21934, Alexandria, Egypt.
3Department of Chemistry, Faculty of Science, Helwan University, Ain-Helwan, 11795 Cairo, Egypt.
Abstract
The present investigation relates to the new method of preparing schiff base of 4-(2-Hydroxy-1,2-diphenyl-ethylideneamino)-1,5-dimethyl-2-phenyl-1,2-dihydropyrazol-3-one as well as the preparation of metallic compounds with certain ions such as (La(III), Gd(III), Co(II), and Cd (II)) in normal and nano-size and their biological applications of their ability to treat colon and breast cancer cells without affecting normal cells. These synthesized compounds have been characterized using different analytical techniques including physicochemical studies such as elemental analysis, electrical conductivity, Uv-visible, IR, nuclear magnetic resonance (NMR), mass spectrometry, magnetic and thermal studies as well as imagining using transmission electron microscopy (TEM). In vitro, the anti-cancer activity of these synthesized compounds was investigated, and their mechanism of action was detected. The results proved that these compounds have the anti-cancer activity against colon cancer (Caco-2) and breast cancer (MCF-7) cell lines at very low concentrations up to 8.27 mg/ml. It was found that the Cd (II) compound showed the highest selectivity against cancer cells without affecting the normal (Vero) cells with selective index (SI) values about 62 times for breast cancer cells and about 51 times for colon cancer cells.
Keywords
Keywords: Schiff base; 4-aminoantipyrine; metallic compounds; physicochemical studies; anti-cancer activity; apoptosis
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