An Efficient Catalyst for the Fabrication of Substituted Pyrroles with Specific Nanomorphology as Potential Antimicrobial and Antioxidant Agents

Mostafa, Eslam A; Zarie, Eman. S.; Shalaby, Al Shimaa G.; Basyouni, Wahid M.; El-Bayouki, Khairy A. M.

doi:10.21608/ejchem.2022.126164.5596

	An Efficient Catalyst for the Fabrication of Substituted Pyrroles with Specific Nanomorphology as Potential Antimicrobial and Antioxidant Agents
Egyptian Journal of Chemistry
Volume 66, Issue 1, January 2023, Page 323-334 PDF (2.85 MB)
Document Type: Original Article
DOI: 10.21608/ejchem.2022.126164.5596
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Authors
Eslam A Mostafa ¹; Eman. S. Zarie ²; Al Shimaa G. Shalaby³; Wahid M. Basyouni¹; Khairy A. M. El-Bayouki¹
¹Organometallic and Organometalloid Chemistry Department, National Research Centre, Dokki 12622, Cairo, Egypt
²Department of Therapeutical Chemistry, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki 12311, Giza, Egypt
³Chemistry of Natural and Microbial Products Department, Pharmaceutical and Drug Industries Research Institute, National Research Centre, Dokki, 12622, Cairo, Egypt
Abstract
Highly typical tetra-substituted pyrroles 4a-j were prepared by the condensation of 1,3-dicarbonyl compounds, benzoin, and ammonium acetate via a one-pot hydrothermal synthesis procedure in the presence of sulfamic acid (SA), as a solid-phase organic catalyst which has recently become quite popular. The efficiency of SA as a new catalyst and ZnCl2 as traditional catalyst in the synthesis of 1-(2-methyl-4,5-diphenyl-1H-pyrrol-3-yl)ethanone 4a was performed as an example for the present comparison. Scanning electron microscopy (SEM) was used to compare the morphologies of the 1-(2-methyl-4,5-diphenyl-1H-pyrrol-3-yl)ethanone films 4a that prepared by those catalysts. An appropriate ratio of sulfamic acid was enough to start the reaction with a higher yield and a higher surface area to volume ratio. Besides, it provided nanoscale-interpenetrating networks with homogenous structures. The chemical structure of the target compounds was characterized by NMR and FTIR spectroscopy. In addition, the prepared compounds were evaluated to study their antimicrobial and antioxidant activities.
Keywords
nano structures; multicomponent reaction; pyrrole; sulfamic acid; solid acids; antimicrobial activity; antioxidant activity


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