Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)
naeem, E., El-Ghoneimy, A., Ahmed, H. (2022). Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae). EKB Journal Management System, 5(1), 83-101. doi: 10.21608/svu.2022.105385.1158
ereen naeem; Ashraf El-Ghoneimy; Hassan Ahmed. "Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)". EKB Journal Management System, 5, 1, 2022, 83-101. doi: 10.21608/svu.2022.105385.1158
naeem, E., El-Ghoneimy, A., Ahmed, H. (2022). 'Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)', EKB Journal Management System, 5(1), pp. 83-101. doi: 10.21608/svu.2022.105385.1158
naeem, E., El-Ghoneimy, A., Ahmed, H. Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae). EKB Journal Management System, 2022; 5(1): 83-101. doi: 10.21608/svu.2022.105385.1158

Anti-inflammatory activities of a sulfated polysaccharide isolated from the brown seaweed Padina boergesenii (Phaeophyceae, Dictyotaceae)

SVU-International Journal of Veterinary Sciences
Article 8, Volume 5, Issue 1 - Serial Number 11, March 2022, Page 83-101  XML PDF (685.6 K)
Document Type: Research article
DOI: 10.21608/svu.2022.105385.1158
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Authors
ereen naeem email 1; Ashraf El-Ghoneimy1; Hassan Ahmedorcid 2
1Department of Pharmacology, Faculty of Veterinary Medicine, South Valley University, Qena, 83523, Egypt
2Physiology department, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt
Abstract
Brown algae (BA) have recently gained high interest as a beneficial source of pharmacological numerous invaluable active constituents. Subsequently, water-soluble polysaccharides of BA attracted the attention of researchers worldwide due to their anticancer and antioxidant activities. This study was carried out to evaluate the anti-inflammatory activity of polysaccharides (PLS) extract of Padina boergesenii brown algae. Xylene produced-ear inflammation and carrageenan produced-paw edema models were used in this study. The PLS doses of 75, 125, 250, 500, 750, 1000mg/kg were tested. Our obtained data revealed that PLS inhibited the inflammatory reactions of both models in a dose-dependent manner. Interestingly, the anti-inflammatory effect of PLS is associated with lowering of nitric oxide and MDA free radicals and pro-inflammatory cytokines: IL- 1β, IL-6, and TNF-α level. This data highlights the therapeutic significance of isolated PLS. As this polysaccharide possesses high anti-inflammatory activity in comparison to the anti-inflammatory drug diclofenac, therefore this natural compound could be recommended as a new effective remedy for inflammation.
Keywords
Anti-inflammatory activities; sulfated polysaccharide; seaweed Padina boergesenii; antioxidants
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