Aminopyridine Transition Metals Complexes; Characterization, Application and Molecular Orbital Calculation | ||||
| Benha Journal of Applied Sciences | ||||
| Article 35, Volume 5, Issue 7 part (1) - (2), October 2020, Page 231-243 PDF (1.22 MB) | ||||
| Document Type: Original Research Papers | ||||
| DOI: 10.21608/bjas.2020.228550 | ||||
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| Authors | ||||
| M.E. Moustafa1; N.M. Meshal1; M.I. Ayad2; O.A. Goda1 | ||||
| 1Chemistry Department, Faculty of Science, Benha University, Benha, Egypt | ||||
| 2Chemistry Department, Faculty of Science, Menofia University, Shiben El - kom, Egypt | ||||
| Abstract | ||||
| Synthesis and characterization of nine complexes formed from the reaction of metal ion salts (chloride or acetate) of Mn2+, Co2+, Ni2+, Cu2+, Zn2+ and Cd2+ (I – IX) and 4-aminopyridine (4Am) with variable stoichiometric ratios were studied and their chemical structures were discussed. The prepared complexes were characterized by different chemical and physical techniques. The antimicrobial activity of the studied complexes was tested against representative bacteria and fungi. The results suggested the high - to - moderate activities against the tested organisms compared to ampicillin taken as a standard drug. The cytotoxic activities of some selected complexes were tested against Lung carcinoma cells A-549 cell line. The results obtained showed that the complexes are considered to have high to moderate activity. The catalytic activity of Ni(4AM) (1:4) complex was tested for the removal of orange G (OG+) dye from waste water sample where almost complete removal of the dye was performed after 90 min. Molecular modeling and quantum chemical parameters of the Mn2+, Co2+, Ni2+ and Zn2+ complexes were studied and calculated. Also, the total density function, deformation density function and frontier orbital energy were determined using DFT method | ||||
| Keywords | ||||
| 4–aminopyridine; transition metal complexes; biological and catalytic activities; molecular orbital calculation | ||||
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