The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI)
Hussein, A., Wassef, M., amer, M., Abdelshafy, A., Fahmy, R. (2022). The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI). EKB Journal Management System, 31(2), 13-17. doi: 10.21608/ejmm.2022.228614
Amira Farouk Hussein; Mona Wassef; mahmoud mostafa amer; Aya Abdelshafy; Radwa Fahmy. "The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI)". EKB Journal Management System, 31, 2, 2022, 13-17. doi: 10.21608/ejmm.2022.228614
Hussein, A., Wassef, M., amer, M., Abdelshafy, A., Fahmy, R. (2022). 'The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI)', EKB Journal Management System, 31(2), pp. 13-17. doi: 10.21608/ejmm.2022.228614
Hussein, A., Wassef, M., amer, M., Abdelshafy, A., Fahmy, R. The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI). EKB Journal Management System, 2022; 31(2): 13-17. doi: 10.21608/ejmm.2022.228614

The Effect of Intrauterine Candida Colonization on Pregnancy Outcome Following Intra-cytoplasmic Sperm Injection (ICSI)

Egyptian Journal of Medical Microbiology
Article 3, Volume 31, Issue 2, April 2022, Page 13-17  XML PDF (251.3 K)
Document Type: New and original researches in the field of Microbiology.
DOI: 10.21608/ejmm.2022.228614
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Authors
Amira Farouk Hussein1; Mona Wassef2; mahmoud mostafa amer3; Aya Abdelshafy email 4; Radwa Fahmy2
1Department of Clinical and chemical pathology, Faculty of Medicine, Cairo University, Cairo, Egypt
2Department of Gynecology and Obstetrics, Faculty of medicine, Cairo University, Cairo, Egypt
3prof of microbiology department ,faculty of science benha uni
4Department of Botany and Microbiology, Faculty of science, Banha University, Qalyuia, Egypt
Abstract
Background: Infertility is caused by numerous anatomical and hormonal factors; however, the role of ascending colonization from vaginal microbiota in infertility is not properly addressed. C.albicans, the most common yeast retrieved from vagina is associated with 61.53% cases of infertility while C.species is associated with 38.46% 1. Intrauterine Candida colonization and its effect on ICSI are still under study and need to be explored further. Objective: This work aimsis to detect the effect of Candida colonization of the uterus in patients undergoing ICSI cycle and clinical pregnancy rate. Methodology: Menstrual blood flow sample at day two induction cycles is subjected to culture and identification of growing organisms. Growth and identification was correlated to Success of ICSI. Predetermined criteria were set up for selection of patients. Results: 69.2% of females with positive growth had failed the ICSI trial with p value 0.04, while 94.4% of patients with no culture growth had successful ICSI with p value 0.0001. Samples with growth of mixed Candida species with bacterial isolates either gram positive and /or gram negative showed 100% failed trials. Samples showed pure growth of Candida albicans or Candida spp. had positive ICSI with p value <0.001. Conclusion: Pure Candida colonization does not seem to affect ICSI outcome; in contrary, mixed Candida with gram positive and/or negative colonization affect pregnancy rate negatively. This could be due to microbial interactions and increasing the ability of Candida to turn into the pathogenic state when mixed with other microorganisms. Screening of females and administration of antifungals and/or antibiotics before ICSI is recommended.
Keywords
Microbiota; upper genital tract; ICSI; clinical pregnancy rate
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