Anti Cancer effect of two new synthized hetero cyclic compounds. | ||||
| Biochemistry Letters | ||||
| Article 1, Volume 18, Issue 1, 2022, Page 1-15 PDF (812.14 K) | ||||
| Document Type: Original Article | ||||
| DOI: 10.21608/blj.2022.229065 | ||||
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| Authors | ||||
| A.T. Keshta1; Mohamed Moustafa2; Hanaa Ashour2; Faten Zahran1 | ||||
| 1Biochemistry Division, Chemistry Department, Faculty of Science, Zagazig university | ||||
| 2Chemistry Department , Faculty of science ,Suez Canal Universty . | ||||
| Abstract | ||||
| Background: Thiazole derivatives are a category of hetero cyclic compounds that large spectrum of biological activities.Aim: This study aim to study the anti cancer effect of thiazole derivatives invitro and invivo.Methods: Synthesis of thiazole derivatives were examined invitro and invivo .Results: Invitro , IC50 of Compound1 on different human lines colon cancer, breast cancer and liver cancer were found 4.7 ug/ml, 4.8 ug/ml and 11 ug /ml respectively. While IC50 value for Compound 2 were found 9.5 ug/ml , 9.6 ug/ml and 18 ug /ml respectively. Invivo , these compounds were safe up to 500 mg/Kg.Although the most effective doses was 15 mg/kg for Compound1 and Compound2. Thiazole derivatives showed a significant reduction in the volume and count of Ehrlich ascites carcinoma and improve hematological parameters ,liver and kidney functions.Conclusion: Thiazole derivatives have apotent antitumor activity . | ||||
| Keywords | ||||
| Anticancer; Thiazole derivatives | ||||
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