Effect of Date Palm (Phoenix dactylifera L.) seeds Mixed with Burger on CCl4-induced Hepatotoxicity and Oxidative Stress in Rats | ||||
| مجلة بحوث التربية النوعية | ||||
| Article 13, Volume 2022, Issue 66, April 2022, Page 757-782 PDF (305.72 K) | ||||
| Document Type: مقالات علمیة محکمة | ||||
| DOI: 10.21608/mbse.2022.125859.1139 | ||||
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| Authors | ||||
نانيس يوسف المتولي السيد عوض   1; ريحاب ابراهيم تاج الدين ابراهيم2
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| 1قسم الاقتصاد المنزلي، کلية التربية النوعية، جامعة المنصورة، المنصورة، جمهورية مصر العربية | ||||
| 2کلية التربية النوعية، جامعة الزقازيق | ||||
| Abstract | ||||
| Date palm have excellent antioxidant activity due to containing high flavonoids and phenolic and has been cited for the treatment of liver problems. To inspect the hepatoprotective activity of burgers fortified and preserved using date in carbon tetrachloride (CCl4)-induced Hepatotoxicity in rats, thirty-six rats were divided into two groups, the first G (1) was negative control, rats of second group were injected by 0.5 ml/rat CCl4 in paraffin oil 50 % (3 ml/kg of body weight) twice a week for two weeks to induce hepatointoxication. Then, blood samples were collected to ensure occurrence of liver injury, after that were divided into 5 groups, G (2) Hepatointoxicated rats as a positive control and fed on basal diet only. G (3) Injected rats by CCl4 were fed on basal diet with burgers control, G (4, 5 and 6) Injected rats by CCl4 were fed on basal diet with preserved burgers using date seed (10, 20 and 30g /kg). Results demonstrated that burgers fortified and preserved using date seed revealed significant improvement in CCl4-induced indicators hemoglobin (HB) and packed cell volume (PCV), (AST, ALT and ALP) liver function parameters. Both serum creatinine and uric acid levels were significantly decreased and nitric oxide (NO). Also restored the antioxidant enzymes activities (glutathione S-transferase (GST), Catalase (CAT) and superoxide dismutase (SOD)) that were deficient after CCl4 induction. The Date Palm seeds might be a promising choice for hepatoprotective against CCl4-induced liver intoxication. It can be utilized as natural preservative additive in suggestive formulations as functional foods. | ||||
| Keywords | ||||
| date palm; polyphenols; antioxidant; CCL4 and Hepatotoxicity | ||||
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