Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model
Galal, O., Mostafa, A., Mohamed, H., Ahmed, A., Hashim, M., Mohamed, N. (2022). Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model. EKB Journal Management System, 5(2), 136-151. doi: 10.21608/svuijm.2022.131434.1301
Omyma Galal; Ahmed Mostafa; Haytham Mohamed; Ahmed R.H. Ahmed; Marwa S. Hashim; Nagwa Mohamed. "Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model". EKB Journal Management System, 5, 2, 2022, 136-151. doi: 10.21608/svuijm.2022.131434.1301
Galal, O., Mostafa, A., Mohamed, H., Ahmed, A., Hashim, M., Mohamed, N. (2022). 'Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model', EKB Journal Management System, 5(2), pp. 136-151. doi: 10.21608/svuijm.2022.131434.1301
Galal, O., Mostafa, A., Mohamed, H., Ahmed, A., Hashim, M., Mohamed, N. Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model. EKB Journal Management System, 2022; 5(2): 136-151. doi: 10.21608/svuijm.2022.131434.1301

Cardioprotective Effects of Nano-Vitamin D on Isoprenaline-Induced Myocardial Infarction Rat Model

SVU-International Journal of Medical Sciences
Article 14, Volume 5, Issue 2, July 2022, Page 136-151  XML PDF (327.84 K)
Document Type: Original research articles
DOI: 10.21608/svuijm.2022.131434.1301
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Authors
Omyma Galal1; Ahmed Mostafa2; Haytham Mohamed3; Ahmed R.H. Ahmedorcid 4; Marwa S. Hashim5; Nagwa Mohamed email 2
1Department of Medical Physiology, Faculty of Medicine, Assiut University, Assiut, Egypt.
2Department of Medical Physiology, Faculty of Medicine, Sohag University, Sohag, Egypt
3Department of Medical Physiology, Faculty of Medicine, South Valley University, Qena, Egypt
4Department of Pathology, Faculty of Medicine, Sohag University, Sohag, Egypt
5Department of Biochemistry, Faculty of Medicine, Sohag University, Sohag, Egypt.
Abstract
Background: Cardiovascular disease (CVD) is a public health problem accounting for 17.9 million deaths worldwide in 2019. Vitamin D is a fat-soluble vitamin that has various cardioprotective actions and its deficiency is associated with a variety of CVDs. Nano systems for vitamin D may overcome the variable oral bioavailability, poor water solubility and chemical degradation of vitamin D.
Objectives: The potential cardioprotective effect of oral vitamin D and vitamin D nanoparticles was evaluated on isoprenaline induced myocardial infarction (MI) rat model.
Materials and method: the study evaluated the effect of vitamin D and vitamin D nanoparticles on MI rate models. MI induced by isoprenaline 100 mg/ kg on the last two days of the 30 day treatment period. We analyzed cardiac injury, lipid peroxidation markers and lipid profile.
Results: isoprenaline treated rats show marked elevation in cardiac troponin-I (cTn-I), and malondialdehyde (MDA), (p value <0.0001). Oral vitamin D reduced cTn-I and MDA levels and improved lipid profile. Vitamin D nanoparticles enhance the cardioprotective effect of conventional vitamin D.
Conclusion: vitamin D nanoparticles have a more efficient cardioprotective effect against isoprenaline induced MI in rats compared to oral conventional vitamin D.
Keywords
myocardial infarction; isoprenaline; vitamin D; vitamin D nanoparticles
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